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NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a herpesvirus that is linked to Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman’s disease (MCD). KSHV establishes persistent latent infection in the human host. KSHV undergoes periods of spontaneous reactivation wher...

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Detalles Bibliográficos
Autores principales: Ma, Zhe, Hopcraft, Sharon E., Yang, Fan, Petrucelli, Alex, Guo, Haitao, Ting, Jenny P-Y, Dittmer, Dirk P., Damania, Blossom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426799/
https://www.ncbi.nlm.nih.gov/pubmed/28459883
http://dx.doi.org/10.1371/journal.ppat.1006350