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Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)

Distortion-product otoacoustic emissions (DPOAEs) arise in the cochlea in response to two tones with frequencies f(1) and f(2) and mainly consist of two components, a nonlinear-distortion and a coherent-reflection component. Wave interference between these components limits the accuracy of DPOAEs wh...

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Autores principales: Zelle, Dennis, Lorenz, Lisa, Thiericke, John P., Gummer, Anthony W., Dalhoff, Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Acoustical Society of America 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426960/
https://www.ncbi.nlm.nih.gov/pubmed/28599560
http://dx.doi.org/10.1121/1.4982923
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author Zelle, Dennis
Lorenz, Lisa
Thiericke, John P.
Gummer, Anthony W.
Dalhoff, Ernst
author_facet Zelle, Dennis
Lorenz, Lisa
Thiericke, John P.
Gummer, Anthony W.
Dalhoff, Ernst
author_sort Zelle, Dennis
collection PubMed
description Distortion-product otoacoustic emissions (DPOAEs) arise in the cochlea in response to two tones with frequencies f(1) and f(2) and mainly consist of two components, a nonlinear-distortion and a coherent-reflection component. Wave interference between these components limits the accuracy of DPOAEs when evaluating the function of the cochlea with conventional continuous stimulus tones. Here, DPOAE components are separated in the time domain from DPOAE signals elicited with short stimulus pulses. The extracted nonlinear-distortion components are used to derive estimated distortion-product thresholds (EDPTs) from semi-logarithmic input-output (I/O) functions for 20 normal-hearing and 21 hearing-impaired subjects. I/O functions were measured with frequency-specific stimulus levels at eight frequencies f(2) = 1,…, 8 kHz (f(2)/f(1) = 1.2). For comparison, DPOAEs were also elicited with continuous primary tones. Both acquisition paradigms yielded EDPTs, which significantly correlated with behavioral thresholds (p < 0.001) and enabled derivation of estimated hearing thresholds (EHTs) from EDPTs using a linear regression relationship. DPOAE-component separation in the time domain significantly reduced the standard deviation of EHTs compared to that derived from continuous DPOAEs (p < 0.01). In conclusion, using frequency-specific stimulus levels and DPOAE-component separation increases the reliability of DPOAE I/O functions for assessing cochlear function and estimating behavioral thresholds.
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spelling pubmed-54269602017-05-12 Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa) Zelle, Dennis Lorenz, Lisa Thiericke, John P. Gummer, Anthony W. Dalhoff, Ernst J Acoust Soc Am Psychological and Physiological Acoustics Distortion-product otoacoustic emissions (DPOAEs) arise in the cochlea in response to two tones with frequencies f(1) and f(2) and mainly consist of two components, a nonlinear-distortion and a coherent-reflection component. Wave interference between these components limits the accuracy of DPOAEs when evaluating the function of the cochlea with conventional continuous stimulus tones. Here, DPOAE components are separated in the time domain from DPOAE signals elicited with short stimulus pulses. The extracted nonlinear-distortion components are used to derive estimated distortion-product thresholds (EDPTs) from semi-logarithmic input-output (I/O) functions for 20 normal-hearing and 21 hearing-impaired subjects. I/O functions were measured with frequency-specific stimulus levels at eight frequencies f(2) = 1,…, 8 kHz (f(2)/f(1) = 1.2). For comparison, DPOAEs were also elicited with continuous primary tones. Both acquisition paradigms yielded EDPTs, which significantly correlated with behavioral thresholds (p < 0.001) and enabled derivation of estimated hearing thresholds (EHTs) from EDPTs using a linear regression relationship. DPOAE-component separation in the time domain significantly reduced the standard deviation of EHTs compared to that derived from continuous DPOAEs (p < 0.01). In conclusion, using frequency-specific stimulus levels and DPOAE-component separation increases the reliability of DPOAE I/O functions for assessing cochlear function and estimating behavioral thresholds. Acoustical Society of America 2017-05 2017-05-11 /pmc/articles/PMC5426960/ /pubmed/28599560 http://dx.doi.org/10.1121/1.4982923 Text en © 2017 Author(s). 0001-4966/2017/141(5)/3203/17 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Psychological and Physiological Acoustics
Zelle, Dennis
Lorenz, Lisa
Thiericke, John P.
Gummer, Anthony W.
Dalhoff, Ernst
Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title_full Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title_fullStr Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title_full_unstemmed Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title_short Input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
title_sort input-output functions of the nonlinear-distortion component of distortion-product otoacoustic emissions in normal and hearing-impaired human earsa)
topic Psychological and Physiological Acoustics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426960/
https://www.ncbi.nlm.nih.gov/pubmed/28599560
http://dx.doi.org/10.1121/1.4982923
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