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Hyperlipidemia Alters the Pharmacokinetics of Posaconazole and Vincristine Upon Co-Administration in Rats

OBJECTIVES: Co-administration of posaconazole (PSZ) and vincristine (VCR) in the treatment of patients with acute lymphoblastic leukemia increases the neurotoxicity of VCR. Our aim is to study the effect of increased lipoprotein levels on the pharmacokinetics of PSZ and VCR upon co-administration in...

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Detalles Bibliográficos
Autores principales:	Khalil, Hadeel A., ElKhatib, Mohammed A. W., Belal, Tarek S., El-Yazbi, Ahmed F., Hamdy, Dalia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2017
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427049/ https://www.ncbi.nlm.nih.gov/pubmed/28299646 http://dx.doi.org/10.1007/s40268-017-0178-8

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