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Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People

Several brain regions and connectivity networks may be altered as aging occurs. We are interested in investigating if resting-state functional magnetic resonance imaging (RS-fMRI) can also be valid as an indicator of individual differences in association with inhibition performance among aged (inclu...

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Autores principales: Lee, Hsing-Hao, Hsieh, Shulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427072/
https://www.ncbi.nlm.nih.gov/pubmed/28553253
http://dx.doi.org/10.3389/fpsyg.2017.00766
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author Lee, Hsing-Hao
Hsieh, Shulan
author_facet Lee, Hsing-Hao
Hsieh, Shulan
author_sort Lee, Hsing-Hao
collection PubMed
description Several brain regions and connectivity networks may be altered as aging occurs. We are interested in investigating if resting-state functional magnetic resonance imaging (RS-fMRI) can also be valid as an indicator of individual differences in association with inhibition performance among aged (including middle-aged) people. Seventy-two healthy adults (40–77 years of age) were recruited. Their RS-fMRI images were acquired and analyzed via two cluster-analysis methods: local synchronization of spontaneous brain activity measured by regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) of blood oxygenation level-dependent signals. After the RS-fMRI acquisition, participants were instructed to perform a stop-signal task, in which the stop signal reaction time (SSRT) was calculated based on the horse-race model. Among participants, the ReHo/fALFF and SSRT were correlated with and without partialling-out the effect of age. The results of this study showed that, although aging may alter brain networks, the spontaneous activity of the age-related brain networks can still serve as an effective indicator of individual differences in association with inhibitory performance in healthy middle-aged and elderly people. This is the first study to use both ReHo and fALFF on the same dataset for conjunction analyses showing the relationship between stopping performance and RS-fMRI in the elderly population. The relationship may have practical clinical applications. Based on the overall results, the current study demonstrated that the bilateral inferior frontal gyrus and parts of the default mode network activation were negatively correlated with SSRT, suggesting that they have crucial roles in inhibitory function. However, the pre-supplementary motor area (pre-SMA) and SMA played only a small role during the resting state in association with stopping performance.
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spelling pubmed-54270722017-05-26 Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People Lee, Hsing-Hao Hsieh, Shulan Front Psychol Psychology Several brain regions and connectivity networks may be altered as aging occurs. We are interested in investigating if resting-state functional magnetic resonance imaging (RS-fMRI) can also be valid as an indicator of individual differences in association with inhibition performance among aged (including middle-aged) people. Seventy-two healthy adults (40–77 years of age) were recruited. Their RS-fMRI images were acquired and analyzed via two cluster-analysis methods: local synchronization of spontaneous brain activity measured by regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) of blood oxygenation level-dependent signals. After the RS-fMRI acquisition, participants were instructed to perform a stop-signal task, in which the stop signal reaction time (SSRT) was calculated based on the horse-race model. Among participants, the ReHo/fALFF and SSRT were correlated with and without partialling-out the effect of age. The results of this study showed that, although aging may alter brain networks, the spontaneous activity of the age-related brain networks can still serve as an effective indicator of individual differences in association with inhibitory performance in healthy middle-aged and elderly people. This is the first study to use both ReHo and fALFF on the same dataset for conjunction analyses showing the relationship between stopping performance and RS-fMRI in the elderly population. The relationship may have practical clinical applications. Based on the overall results, the current study demonstrated that the bilateral inferior frontal gyrus and parts of the default mode network activation were negatively correlated with SSRT, suggesting that they have crucial roles in inhibitory function. However, the pre-supplementary motor area (pre-SMA) and SMA played only a small role during the resting state in association with stopping performance. Frontiers Media S.A. 2017-05-12 /pmc/articles/PMC5427072/ /pubmed/28553253 http://dx.doi.org/10.3389/fpsyg.2017.00766 Text en Copyright © 2017 Lee and Hsieh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Lee, Hsing-Hao
Hsieh, Shulan
Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title_full Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title_fullStr Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title_full_unstemmed Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title_short Resting-State fMRI Associated with Stop-Signal Task Performance in Healthy Middle-Aged and Elderly People
title_sort resting-state fmri associated with stop-signal task performance in healthy middle-aged and elderly people
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427072/
https://www.ncbi.nlm.nih.gov/pubmed/28553253
http://dx.doi.org/10.3389/fpsyg.2017.00766
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