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Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease

Cardiovascular diseases are a class of heart or blood vessels diseases, which are now considered to be the leading cause of death globally. A number of recent studies have reported key roles for inflammation in the progression of diseased vessels and systematic heart failure. In particular, endoplas...

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Autores principales: Zhang, Cheng, Syed, Taha Wasim, Liu, Renjing, Yu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427082/
https://www.ncbi.nlm.nih.gov/pubmed/28553639
http://dx.doi.org/10.3389/fcvm.2017.00029
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author Zhang, Cheng
Syed, Taha Wasim
Liu, Renjing
Yu, Jun
author_facet Zhang, Cheng
Syed, Taha Wasim
Liu, Renjing
Yu, Jun
author_sort Zhang, Cheng
collection PubMed
description Cardiovascular diseases are a class of heart or blood vessels diseases, which are now considered to be the leading cause of death globally. A number of recent studies have reported key roles for inflammation in the progression of diseased vessels and systematic heart failure. In particular, endoplasmic reticulum (ER) stress, which is mechanistically implicated in inflammation and autophagy, has now been associated with pathophysiological states in the cardiovascular system. Autophagy has also been identified as an important process in the progression of multiple cardiovascular diseases such as in atherosclerosis plaque progression and ischemia and/or reperfusion. In light of the above, it has been proposed that a link between inflammation, autophagy, and ER stress may exist that contribute to diseases of the heart and its supporting vessels. This review highlights current knowledge on the cross talk between these three biological processes, and the potential of targeting this pathway as a therapeutic approach for cardiovascular disorders and its related diseases.
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spelling pubmed-54270822017-05-26 Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease Zhang, Cheng Syed, Taha Wasim Liu, Renjing Yu, Jun Front Cardiovasc Med Cardiovascular Medicine Cardiovascular diseases are a class of heart or blood vessels diseases, which are now considered to be the leading cause of death globally. A number of recent studies have reported key roles for inflammation in the progression of diseased vessels and systematic heart failure. In particular, endoplasmic reticulum (ER) stress, which is mechanistically implicated in inflammation and autophagy, has now been associated with pathophysiological states in the cardiovascular system. Autophagy has also been identified as an important process in the progression of multiple cardiovascular diseases such as in atherosclerosis plaque progression and ischemia and/or reperfusion. In light of the above, it has been proposed that a link between inflammation, autophagy, and ER stress may exist that contribute to diseases of the heart and its supporting vessels. This review highlights current knowledge on the cross talk between these three biological processes, and the potential of targeting this pathway as a therapeutic approach for cardiovascular disorders and its related diseases. Frontiers Media S.A. 2017-05-12 /pmc/articles/PMC5427082/ /pubmed/28553639 http://dx.doi.org/10.3389/fcvm.2017.00029 Text en Copyright © 2017 Zhang, Syed, Liu and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Zhang, Cheng
Syed, Taha Wasim
Liu, Renjing
Yu, Jun
Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title_full Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title_fullStr Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title_full_unstemmed Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title_short Role of Endoplasmic Reticulum Stress, Autophagy, and Inflammation in Cardiovascular Disease
title_sort role of endoplasmic reticulum stress, autophagy, and inflammation in cardiovascular disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427082/
https://www.ncbi.nlm.nih.gov/pubmed/28553639
http://dx.doi.org/10.3389/fcvm.2017.00029
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