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Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

In this study we have applied an integrated system biology approach to characterize the metabolic landscape of Streptomyces ambofaciens and to identify a list of potential metabolic engineering targets for the overproduction of the secondary metabolites in this microorganism. We focused on an often...

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Detalles Bibliográficos
Autores principales:	Fondi, Marco, Pinatel, Eva, Talà, Adelfia, Damiano, Fabrizio, Consolandi, Clarissa, Mattorre, Benedetta, Fico, Daniela, Testini, Mariangela, De Benedetto, Giuseppe E., Siculella, Luisa, De Bellis, Gianluca, Alifano, Pietro, Peano, Clelia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427115/ https://www.ncbi.nlm.nih.gov/pubmed/28553270 http://dx.doi.org/10.3389/fmicb.2017.00835

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