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Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer

PURPOSE: We have previously described a novel pathway controlling drug resistance, epithelial-to-mesenchymal transition (EMT) and stemness in breast cancer cells. Upstream in the pathway, three miRs (miR-106b, miR-93 and miR-25) target EP300, a transcriptional activator of E-cadherin. Upregulation o...

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Detalles Bibliográficos
Autores principales:	Asaduzzaman, Muhammad, Constantinou, Stephanie, Min, Haoxiang, Gallon, John, Lin, Meng-Lay, Singh, Poonam, Raguz, Selina, Ali, Simak, Shousha, Sami, Coombes, R. Charles, Lam, Eric W.-F., Hu, Yunhui, Yagüe, Ernesto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427146/ https://www.ncbi.nlm.nih.gov/pubmed/28341962 http://dx.doi.org/10.1007/s10549-017-4202-z

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