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No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?

The existence of input plasticity in the deep cerebellar nuclear (DCN) cells of the adult cerebellum could have profound implications for our understanding of cerebellar function. Whereas the existence of plastic changes in mossy fiber (mf) synaptic responses in DCN neurons has been demonstrated in...

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Autores principales: Mogensen, Hannes, Bengtsson, Fredrik, Jörntell, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427151/
https://www.ncbi.nlm.nih.gov/pubmed/28032320
http://dx.doi.org/10.1007/s12311-016-0839-0
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author Mogensen, Hannes
Bengtsson, Fredrik
Jörntell, Henrik
author_facet Mogensen, Hannes
Bengtsson, Fredrik
Jörntell, Henrik
author_sort Mogensen, Hannes
collection PubMed
description The existence of input plasticity in the deep cerebellar nuclear (DCN) cells of the adult cerebellum could have profound implications for our understanding of cerebellar function. Whereas the existence of plastic changes in mossy fiber (mf) synaptic responses in DCN neurons has been demonstrated in juvenile slices, there has so far been no direct demonstration of this form of plasticity in the adult cerebellum in vivo. In the present paper, we recorded from neurons in the anterior interposed nucleus (AIN) and stimulated the spinocerebellar tracts (SCT) directly or via the skin to obtain mf activation and the inferior olive to activate climbing fibers (cfs) in the nonanesthetized, adult, decerebrated cat. We used three different types of protocols that theoretically could be expected to induce plasticity, each of which involved episodically intense afferent activation lasting for 10 min. These were conjunctive mf-cf activation, which effectively induces plasticity in cortical neurons; mf and cf activation in a pattern resembling the protocol for inducing classical conditioning; and conjunctive activation of two excitatory mf inputs. None of these protocols had any statistically significant effect on the evoked responses in the AIN neurons. We conclude that the input plasticity for excitatory mfs in the AIN cells of the adult cerebellum in vivo is likely to be less effective than that of parallel fiber synaptic inputs in cerebellar cortical cells, at least in the timespan of 1 h.
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spelling pubmed-54271512017-05-26 No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo? Mogensen, Hannes Bengtsson, Fredrik Jörntell, Henrik Cerebellum Article The existence of input plasticity in the deep cerebellar nuclear (DCN) cells of the adult cerebellum could have profound implications for our understanding of cerebellar function. Whereas the existence of plastic changes in mossy fiber (mf) synaptic responses in DCN neurons has been demonstrated in juvenile slices, there has so far been no direct demonstration of this form of plasticity in the adult cerebellum in vivo. In the present paper, we recorded from neurons in the anterior interposed nucleus (AIN) and stimulated the spinocerebellar tracts (SCT) directly or via the skin to obtain mf activation and the inferior olive to activate climbing fibers (cfs) in the nonanesthetized, adult, decerebrated cat. We used three different types of protocols that theoretically could be expected to induce plasticity, each of which involved episodically intense afferent activation lasting for 10 min. These were conjunctive mf-cf activation, which effectively induces plasticity in cortical neurons; mf and cf activation in a pattern resembling the protocol for inducing classical conditioning; and conjunctive activation of two excitatory mf inputs. None of these protocols had any statistically significant effect on the evoked responses in the AIN neurons. We conclude that the input plasticity for excitatory mfs in the AIN cells of the adult cerebellum in vivo is likely to be less effective than that of parallel fiber synaptic inputs in cerebellar cortical cells, at least in the timespan of 1 h. Springer US 2016-12-28 2017 /pmc/articles/PMC5427151/ /pubmed/28032320 http://dx.doi.org/10.1007/s12311-016-0839-0 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Mogensen, Hannes
Bengtsson, Fredrik
Jörntell, Henrik
No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title_full No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title_fullStr No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title_full_unstemmed No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title_short No Medium-Term Spinocerebellar Input Plasticity in Deep Cerebellar Nuclear Neurons In Vivo?
title_sort no medium-term spinocerebellar input plasticity in deep cerebellar nuclear neurons in vivo?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427151/
https://www.ncbi.nlm.nih.gov/pubmed/28032320
http://dx.doi.org/10.1007/s12311-016-0839-0
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