Motor neuron vulnerability and resistance in amyotrophic lateral sclerosis

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate. Importantly, certain lower MN subgroups are relatively resistant to degeneration, even though pathogenic proteins are typically ubi...

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Detalles Bibliográficos
Autores principales: Nijssen, Jik, Comley, Laura H., Hedlund, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427160/
https://www.ncbi.nlm.nih.gov/pubmed/28409282
http://dx.doi.org/10.1007/s00401-017-1708-8

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