Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease characterized by degeneration and premature death of motor neurons. The contribution of mutant TDP-43-mediated damage within motor neurons was evaluated using mice expressing a conditional allele of an ALS-causi...

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Detalles Bibliográficos
Autores principales: Ditsworth, Dara, Maldonado, Marcus, McAlonis-Downes, Melissa, Sun, Shuying, Seelman, Amanda, Drenner, Kevin, Arnold, Eveline, Ling, Shuo-Chien, Pizzo, Donald, Ravits, John, Cleveland, Don W., Da Cruz, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427168/
https://www.ncbi.nlm.nih.gov/pubmed/28357566
http://dx.doi.org/10.1007/s00401-017-1698-6

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