Cargando…

Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats

Defective mismatch repair (MMR) in humans is associated with colon cancer and instability of microsatellites, that is, DNA sequences with one or several nucleotides repeated. Key factors of eukaryotic MMR are the heterodimers MutSα (Msh2-Msh6), which recognizes base-base mismatches and unpaired nucl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villahermosa, Desirée, Christensen, Olaf, Knapp, Karen, Fleck, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2017
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427490/ https://www.ncbi.nlm.nih.gov/pubmed/28341698 http://dx.doi.org/10.1534/g3.117.040816

Ejemplares similares

MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
por: Groothuizen, Flora S, et al.
Publicado: (2015)

MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
por: Iyer, Ravi R., et al.
Publicado: (2010)

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
por: Liu, Yiyong, et al.
Publicado: (2010)

PCNA–MutSα-mediated binding of MutLα to replicative DNA with mismatched bases to induce apoptosis in human cells
por: Hidaka, Masumi, et al.
Publicado: (2005)

MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia
por: Ezzatizadeh, Vahid, et al.
Publicado: (2014)

The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes
por: Garcia-Gonzalez, Aurian, et al.
Publicado: (2012)

The mismatch repair system (mutS and mutL) in Acinetobacter baylyi ADP1
por: Zhou, Hua, et al.
Publicado: (2020)

A mutated dph3 gene causes sensitivity of Schizosaccharomyces pombe cells to cytotoxic agents
por: Villahermosa, Desirée, et al.
Publicado: (2017)

Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
por: Elez, Marina, et al.
Publicado: (2012)

A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?
por: Zhao, Xiao-Nan, et al.
Publicado: (2016)

Characterisation of the MutS and MutL Proteins from the Pseudomonas avellanae Mismatch Repair (MMR) System
por: Grenga, Lucia, et al.
Publicado: (2012)

MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair
por: Yang, Xiao-Wen, et al.
Publicado: (2022)

Different Roles of Eukaryotic MutS and MutL Complexes in Repair of Small Insertion and Deletion Loops in Yeast
por: Romanova, Nina V., et al.
Publicado: (2013)

Activity of Vsr endonucleases encoded by Neisseria gonorrhoeae FA1090 is influenced by MutL and MutS proteins
por: Adamczyk-Popławska, Monika, et al.
Publicado: (2018)

Inactivation of Genes Encoding MutL and MutS Proteins Influences Adhesion and Biofilm Formation by Neisseria gonorrhoeae
por: Płaczkiewicz, Jagoda, et al.
Publicado: (2019)

Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
por: Ortega, Janice, et al.
Publicado: (2021)

MutS and MutL Are Dispensable for Maintenance of the Genomic Mutation Rate in the Halophilic Archaeon Halobacterium salinarum NRC-1
por: Busch, Courtney R., et al.
Publicado: (2010)

The sliding clamp tethers the endonuclease domain of MutL to DNA
por: Pillon, Monica C., et al.
Publicado: (2015)

Catalytic mechanism of the zinc-dependent MutL endonuclease reaction
por: Fukui, Kenji, et al.
Publicado: (2023)

Inactivation of the DNA Repair Genes mutS, mutL or the Anti-Recombination Gene mutS2 Leads to Activation of Vitamin B(1) Biosynthesis Genes
por: Fukui, Kenji, et al.
Publicado: (2011)

The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease
por: Sherrer, Shanen M., et al.
Publicado: (2018)

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective
por: Zhao, Xiaonan, et al.
Publicado: (2018)

MutSβ exceeds MutSα in dinucleotide loop repair
por: Kantelinen, J, et al.
Publicado: (2010)

8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα
por: Macpherson, Peter, et al.
Publicado: (2005)

8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutSα
por: Macpherson, Peter, et al.
Publicado: (2005)

Adenosine Triphosphate Stimulates Aquifex aeolicus MutL Endonuclease Activity
por: Mauris, Jerome, et al.
Publicado: (2009)

Elp3 and Dph3 of Schizosaccharomyces pombe mediate cellular stress responses through tRNA(Lys)(UUU) modifications
por: Villahermosa, Desirée, et al.
Publicado: (2017)

Functions of MutLα, Replication Protein A (RPA), and HMGB1 in 5′-Directed Mismatch Repair
por: Genschel, Jochen, et al.
Publicado: (2009)

MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases
por: Iyer, Lakshminarayan M, et al.
Publicado: (2008)

The UvrD helicase and its modulation by the mismatch repair protein MutL
por: Matson, Steven W., et al.
Publicado: (2006)

Binding of the regulatory domain of MutL to the sliding β-clamp is species specific
por: Almawi, Ahmad W, et al.
Publicado: (2019)

PCNA activates the MutLγ endonuclease to promote meiotic crossing over
por: Kulkarni, Dhananjaya S., et al.
Publicado: (2020)

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex
por: Kim, Yoori, et al.
Publicado: (2019)

The mismatch repair endonuclease MutLα tethers duplex regions of DNA together and relieves DNA torsional tension
por: Witte, Scott J, et al.
Publicado: (2023)

All three mammalian MutL complexes are required for repeat expansion in a mouse cell model of the Fragile X-related disorders
por: Miller, Carson J., et al.
Publicado: (2020)

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
por: Keogh, Norma, et al.
Publicado: (2017)

Identifying an interaction site between MutH and the C-terminal domain of MutL by crosslinking, affinity purification, chemical coding and mass spectrometry
por: Ahrends, Robert, et al.
Publicado: (2006)

Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα
por: Firnau, May-Britt, et al.
Publicado: (2023)

Physical and functional interactions between Escherichia coli MutL and the Vsr repair endonuclease
por: Heinze, Roger J., et al.
Publicado: (2009)

Analysis of the Interaction Interfaces of the N-Terminal Domain from Pseudomonas aeruginosa MutL
por: Miguel, Virginia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qoib7536v2o253r66tve0akd0j