Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formation

BACKGROUND: Intra-tumoral hypoxia and increases in extracellular level of transforming growth factor β1 (TGF-β1), which are common findings in cancer, are associated with an increased risk of metastasis and mortality. Moreover, metastasis is the leading cause of death of patients with cervical cance...

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Detalles Bibliográficos
Autores principales: Xu, Feifei, Zhang, Jialu, Hu, Guolin, Liu, Lei, Liang, Weijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427545/
https://www.ncbi.nlm.nih.gov/pubmed/28507454
http://dx.doi.org/10.1186/s12935-017-0420-z

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