Alzheimer’s disease, dementia, and stem cell therapy

Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuit...

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Detalles Bibliográficos
Autores principales: Duncan, Thomas, Valenzuela, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427593/
https://www.ncbi.nlm.nih.gov/pubmed/28494803
http://dx.doi.org/10.1186/s13287-017-0567-5
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author Duncan, Thomas
Valenzuela, Michael
author_facet Duncan, Thomas
Valenzuela, Michael
author_sort Duncan, Thomas
collection PubMed
description Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.
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spelling pubmed-54275932017-05-15 Alzheimer’s disease, dementia, and stem cell therapy Duncan, Thomas Valenzuela, Michael Stem Cell Res Ther Review Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development. BioMed Central 2017-05-12 /pmc/articles/PMC5427593/ /pubmed/28494803 http://dx.doi.org/10.1186/s13287-017-0567-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Duncan, Thomas
Valenzuela, Michael
Alzheimer’s disease, dementia, and stem cell therapy
title Alzheimer’s disease, dementia, and stem cell therapy
title_full Alzheimer’s disease, dementia, and stem cell therapy
title_fullStr Alzheimer’s disease, dementia, and stem cell therapy
title_full_unstemmed Alzheimer’s disease, dementia, and stem cell therapy
title_short Alzheimer’s disease, dementia, and stem cell therapy
title_sort alzheimer’s disease, dementia, and stem cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427593/
https://www.ncbi.nlm.nih.gov/pubmed/28494803
http://dx.doi.org/10.1186/s13287-017-0567-5
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