Cargando…

Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection

BACKGROUND: Chronic immune activation is a feature of HIV infection associated with accelerated HIV disease progression. There is conflicting data on the association of biomarkers of immune activation with traditional markers of HIV disease progression; CD4 counts and viral load (VL). OBJECTIVE: The...

Descripción completa

Detalles Bibliográficos
Autores principales: Mhandire, Kudakwashe, Mlambo, Tommy, Zijenah, Lynn Sodai, Duri, Kerina, Mateveke, Kudzaishe, Tshabalala, Mqondisi, Mhandire, Doreen Zvipo, Musarurwa, Cuthbert, Wekare, Petronella Taonga, Mazengera, Lovemore Ronald, Matarira, Hilda Tendisa, Stray-Pedersen, Babill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427702/
https://www.ncbi.nlm.nih.gov/pubmed/28553429
http://dx.doi.org/10.2174/1874613601711010024
_version_ 1783235680891043840
author Mhandire, Kudakwashe
Mlambo, Tommy
Zijenah, Lynn Sodai
Duri, Kerina
Mateveke, Kudzaishe
Tshabalala, Mqondisi
Mhandire, Doreen Zvipo
Musarurwa, Cuthbert
Wekare, Petronella Taonga
Mazengera, Lovemore Ronald
Matarira, Hilda Tendisa
Stray-Pedersen, Babill
author_facet Mhandire, Kudakwashe
Mlambo, Tommy
Zijenah, Lynn Sodai
Duri, Kerina
Mateveke, Kudzaishe
Tshabalala, Mqondisi
Mhandire, Doreen Zvipo
Musarurwa, Cuthbert
Wekare, Petronella Taonga
Mazengera, Lovemore Ronald
Matarira, Hilda Tendisa
Stray-Pedersen, Babill
author_sort Mhandire, Kudakwashe
collection PubMed
description BACKGROUND: Chronic immune activation is a feature of HIV infection associated with accelerated HIV disease progression. There is conflicting data on the association of biomarkers of immune activation with traditional markers of HIV disease progression; CD4 counts and viral load (VL). OBJECTIVE: The study aimed to determine the association of biomarkers of immune activation; interferon (IFN)-γ-induced protein 10 (IP-10) and soluble cluster of differentiation 14 (sCD14) in chronic HIV infection with traditional markers of HIV disease progression. METHODS: We collected demographic data, enumerated CD4 counts and quantified VL in 183 antiretroviral therapy (ART)-naive adults with chronic HIV infection. Plasma concentrations of IP-10 and sCD14 were quantified in the ART-naive adults with chronic HIV infection and 75 HIV-uninfected controls. RESULTS: IP-10 concentrations were significantly higher in the HIV-infected group (median; 257.40pg/ml, IQR; 174.08-376.32) than in the HIV-uninfected (median; 86.19pg/ml, IQR; 67.70-116.39) (P<0.001). Similarly, sCD14 concentrations were significantly higher in the HIV-infected (median; 1.45µg/ml, IQR; 1.02-2.16) group than in the controls (median; 0.89µ/ml, IQR; 0.74-1.18) (P<0.001). High log(10) IP-10 concentrations were positively correlated with high log(10) viral loads (Spearman’s correlation coefficient [R]=0.21, P=0.003) and inversely correlated with low CD4 counts (R= -0.19, P=0.011). In contrast, log(10) sCD14 was not significantly associated with either log(10) viral loads (R=0.03, P=0.707) nor CD4 count (R=-0.04, P=0.568). CONCLUSION: We conclude that plasma sCD14 and IP-10 were elevated in the HIV-infected patients compared to HIV-uninfected individuals possibly due to on-going immune activation. In addition, plasma high concentrations of IP-10 but not sCD14 concentrations are associated with high VL and low CD4 count.
format Online
Article
Text
id pubmed-5427702
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-54277022017-05-26 Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection Mhandire, Kudakwashe Mlambo, Tommy Zijenah, Lynn Sodai Duri, Kerina Mateveke, Kudzaishe Tshabalala, Mqondisi Mhandire, Doreen Zvipo Musarurwa, Cuthbert Wekare, Petronella Taonga Mazengera, Lovemore Ronald Matarira, Hilda Tendisa Stray-Pedersen, Babill Open AIDS J Article BACKGROUND: Chronic immune activation is a feature of HIV infection associated with accelerated HIV disease progression. There is conflicting data on the association of biomarkers of immune activation with traditional markers of HIV disease progression; CD4 counts and viral load (VL). OBJECTIVE: The study aimed to determine the association of biomarkers of immune activation; interferon (IFN)-γ-induced protein 10 (IP-10) and soluble cluster of differentiation 14 (sCD14) in chronic HIV infection with traditional markers of HIV disease progression. METHODS: We collected demographic data, enumerated CD4 counts and quantified VL in 183 antiretroviral therapy (ART)-naive adults with chronic HIV infection. Plasma concentrations of IP-10 and sCD14 were quantified in the ART-naive adults with chronic HIV infection and 75 HIV-uninfected controls. RESULTS: IP-10 concentrations were significantly higher in the HIV-infected group (median; 257.40pg/ml, IQR; 174.08-376.32) than in the HIV-uninfected (median; 86.19pg/ml, IQR; 67.70-116.39) (P<0.001). Similarly, sCD14 concentrations were significantly higher in the HIV-infected (median; 1.45µg/ml, IQR; 1.02-2.16) group than in the controls (median; 0.89µ/ml, IQR; 0.74-1.18) (P<0.001). High log(10) IP-10 concentrations were positively correlated with high log(10) viral loads (Spearman’s correlation coefficient [R]=0.21, P=0.003) and inversely correlated with low CD4 counts (R= -0.19, P=0.011). In contrast, log(10) sCD14 was not significantly associated with either log(10) viral loads (R=0.03, P=0.707) nor CD4 count (R=-0.04, P=0.568). CONCLUSION: We conclude that plasma sCD14 and IP-10 were elevated in the HIV-infected patients compared to HIV-uninfected individuals possibly due to on-going immune activation. In addition, plasma high concentrations of IP-10 but not sCD14 concentrations are associated with high VL and low CD4 count. Bentham Open 2017-04-26 /pmc/articles/PMC5427702/ /pubmed/28553429 http://dx.doi.org/10.2174/1874613601711010024 Text en © 2017 Mhandire et al. https://creativecommons.org/licenses/by/4.0/legalcode This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Mhandire, Kudakwashe
Mlambo, Tommy
Zijenah, Lynn Sodai
Duri, Kerina
Mateveke, Kudzaishe
Tshabalala, Mqondisi
Mhandire, Doreen Zvipo
Musarurwa, Cuthbert
Wekare, Petronella Taonga
Mazengera, Lovemore Ronald
Matarira, Hilda Tendisa
Stray-Pedersen, Babill
Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title_full Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title_fullStr Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title_full_unstemmed Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title_short Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
title_sort plasma ip-10 concentrations correlate positively with viraemia and inversely with cd4 counts in untreated hiv infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427702/
https://www.ncbi.nlm.nih.gov/pubmed/28553429
http://dx.doi.org/10.2174/1874613601711010024
work_keys_str_mv AT mhandirekudakwashe plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT mlambotommy plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT zijenahlynnsodai plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT durikerina plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT matevekekudzaishe plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT tshabalalamqondisi plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT mhandiredoreenzvipo plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT musarurwacuthbert plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT wekarepetronellataonga plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT mazengeralovemoreronald plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT matarirahildatendisa plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection
AT straypedersenbabill plasmaip10concentrationscorrelatepositivelywithviraemiaandinverselywithcd4countsinuntreatedhivinfection