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KCC2 downregulation facilitates epileptic seizures
GABA(A) receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl(−)] concentration, which in adult depends on neuron specific K(+)-Cl(−) cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic anim...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427808/ https://www.ncbi.nlm.nih.gov/pubmed/28279020 http://dx.doi.org/10.1038/s41598-017-00196-7 |