Cargando…

Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults

Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was...

Descripción completa

Detalles Bibliográficos
Autores principales: Joris, Peter J., Plat, Jogchum, Bakker, Stephan J. L., Mensink, Ronald P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428005/
https://www.ncbi.nlm.nih.gov/pubmed/28273891
http://dx.doi.org/10.1038/s41598-017-00205-9
_version_ 1783235740569698304
author Joris, Peter J.
Plat, Jogchum
Bakker, Stephan J. L.
Mensink, Ronald P.
author_facet Joris, Peter J.
Plat, Jogchum
Bakker, Stephan J. L.
Mensink, Ronald P.
author_sort Joris, Peter J.
collection PubMed
description Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules. Endothelial function was assessed at the start and at the end of the study. Cardiometabolic risk markers were measured at baseline, after 12 weeks, and at week 24. Brachial artery flow-mediated vasodilation did not change following long-term magnesium supplementation (0.49 pp; 95% CI: −0.38 to 1.36 pp; P = 0.26). Changes in reactive hyperemia index, retinal microvascular caliber and plasma markers for microvascular endothelial function (sVCAM-1, sICAM-1 and sE-selectin) were also not different. In addition, no effects on serum lipids, plasma glucose, insulin sensitivity, and low-grade systemic inflammation were observed. In conclusion, a daily magnesium supplement of 350 mg for 24 weeks does not improve endothelial function and cardiometabolic risk markers in overweight and obese middle-aged and elderly adults.
format Online
Article
Text
id pubmed-5428005
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-54280052017-05-15 Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults Joris, Peter J. Plat, Jogchum Bakker, Stephan J. L. Mensink, Ronald P. Sci Rep Article Long-term magnesium supplementation improves arterial stiffness, a cardiovascular disease risk marker. Effects on endothelial function may be another mechanism whereby increased magnesium intakes affect cardiovascular risk. Therefore, a 24-week, randomized, double-blind, placebo-controlled trial was performed to examine effects of magnesium supplementation on endothelial function and cardiometabolic risk markers. Fifty-two overweight and obese subjects (30 men and 22 women, age 62 ± 6 years) were randomized to receive either three times daily magnesium (total dose: 350 mg) or placebo capsules. Endothelial function was assessed at the start and at the end of the study. Cardiometabolic risk markers were measured at baseline, after 12 weeks, and at week 24. Brachial artery flow-mediated vasodilation did not change following long-term magnesium supplementation (0.49 pp; 95% CI: −0.38 to 1.36 pp; P = 0.26). Changes in reactive hyperemia index, retinal microvascular caliber and plasma markers for microvascular endothelial function (sVCAM-1, sICAM-1 and sE-selectin) were also not different. In addition, no effects on serum lipids, plasma glucose, insulin sensitivity, and low-grade systemic inflammation were observed. In conclusion, a daily magnesium supplement of 350 mg for 24 weeks does not improve endothelial function and cardiometabolic risk markers in overweight and obese middle-aged and elderly adults. Nature Publishing Group UK 2017-03-07 /pmc/articles/PMC5428005/ /pubmed/28273891 http://dx.doi.org/10.1038/s41598-017-00205-9 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Joris, Peter J.
Plat, Jogchum
Bakker, Stephan J. L.
Mensink, Ronald P.
Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title_full Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title_fullStr Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title_full_unstemmed Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title_short Effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: A randomized controlled trial in overweight/obese adults
title_sort effects of long-term magnesium supplementation on endothelial function and cardiometabolic risk markers: a randomized controlled trial in overweight/obese adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428005/
https://www.ncbi.nlm.nih.gov/pubmed/28273891
http://dx.doi.org/10.1038/s41598-017-00205-9
work_keys_str_mv AT jorispeterj effectsoflongtermmagnesiumsupplementationonendothelialfunctionandcardiometabolicriskmarkersarandomizedcontrolledtrialinoverweightobeseadults
AT platjogchum effectsoflongtermmagnesiumsupplementationonendothelialfunctionandcardiometabolicriskmarkersarandomizedcontrolledtrialinoverweightobeseadults
AT bakkerstephanjl effectsoflongtermmagnesiumsupplementationonendothelialfunctionandcardiometabolicriskmarkersarandomizedcontrolledtrialinoverweightobeseadults
AT mensinkronaldp effectsoflongtermmagnesiumsupplementationonendothelialfunctionandcardiometabolicriskmarkersarandomizedcontrolledtrialinoverweightobeseadults