Cargando…

Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE(2) Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

Exaggerated inflammatory responses in microglia represent one of the major risk factors for various central nervous system’s (CNS) associated pathologies. Release of excessive inflammatory mediators such as prostaglandins and cytokines are the hallmark of hyper-activated microglia. Here we have inve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhatia, Harsharan S., Roelofs, Nora, Muñoz, Eduardo, Fiebich, Bernd L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428011/ https://www.ncbi.nlm.nih.gov/pubmed/28273917 http://dx.doi.org/10.1038/s41598-017-00225-5

Ejemplares similares

Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
por: Bhatia, Harsharan S., et al.
Publicado: (2016)

Licochalcone A Inhibits Prostaglandin E(2) by Targeting the MAPK Pathway in LPS Activated Primary Microglia
por: Bhatia, Harsharan Singh, et al.
Publicado: (2023)

Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling
por: Zhang, Hai-feng, et al.
Publicado: (2020)

The p38(MAPK)-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission
por: Beamer, Edward, et al.
Publicado: (2021)

Ca(2+)/Calmodulin Modulates TRPV1 Activation by Capsaicin
por: Rosenbaum, Tamara, et al.
Publicado: (2004)

Anticolitic Effect of Berberine in Rat Experimental Model: Impact of PGE2/p38 MAPK Pathways
por: Jia, Li, et al.
Publicado: (2020)

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis
por: Ronkina, Natalia, et al.
Publicado: (2016)

Selective inhibition of the p38α MAPK–MK2 axis inhibits inflammatory cues including inflammasome priming signals
por: Wang, Chun, et al.
Publicado: (2018)

p38 MAPK, microglial signaling, and neuropathic pain
por: Ji, Ru-Rong, et al.
Publicado: (2007)

Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38(MAPK)-induced heat shock protein 27 phosphorylation
por: Shiryaev, Alexey, et al.
Publicado: (2011)

Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38 MAPK/MK2 pathway
por: O'Dea, Kieran P., et al.
Publicado: (2011)

p38(MAPK)/MK2 signaling stimulates host cells autophagy pathways to restrict Salmonella infection
por: Suwandi, Abdulhadi, et al.
Publicado: (2023)

Endogenous PGE(2) induces MCP-1 expression via EP4/p38 MAPK signaling in melanoma
por: TANG, MINGRUI, et al.
Publicado: (2013)

Integrating TRPV1 Receptor Function with Capsaicin Psychophysics
por: Smutzer, Gregory, et al.
Publicado: (2016)

p38(MAPK)/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex
por: Tiedje, Christopher, et al.
Publicado: (2015)

Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1
por: Chen, Wei-Ting, et al.
Publicado: (2018)

Epinephrine modulates Na(+)/K(+) ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2
por: El Moussawi, Layla, et al.
Publicado: (2018)

Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats
por: Wang, Qiuyue, et al.
Publicado: (2022)

The p38/MK2 Axis in Monocytes of Fibromyalgia Syndrome Patients: An Explorative Study
por: Nugraha, Boya, et al.
Publicado: (2021)

The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells
por: Iwata, Yoshika, et al.
Publicado: (2021)

Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE(2 )in primary rat microglia
por: Schlachetzki, Johannes CM, et al.
Publicado: (2010)

Paeonol alleviates neuropathic pain by modulating microglial M1 and M2 polarization via the RhoA/p38MAPK signaling pathway
por: Li, Xin, et al.
Publicado: (2023)

Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice
por: Wang, Sung Eun, et al.
Publicado: (2018)

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury
por: Ashraf, Muhammad Imtiaz, et al.
Publicado: (2014)

IL‐33 regulates cytokine production and neutrophil recruitment via the p38 MAPK‐activated kinases MK2/3
por: McCarthy, Pierre C, et al.
Publicado: (2018)

Acidification of rat TRPV1 alters the kinetics of capsaicin responses
por: Neelands, Torben R, et al.
Publicado: (2005)

Rational discovery of new capsaicin analogues as TRPV1 activators
por: Cáceres, Javier, et al.
Publicado: (2015)

Lactate is a potent inhibitor of the capsaicin receptor TRPV1
por: de la Roche, Jeanne, et al.
Publicado: (2016)

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin
por: Yang, Fan, et al.
Publicado: (2017)

Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors
por: Tsvetkov, E.A., et al.
Publicado: (2017)

Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation
por: Munjuluri, Sreepadaarchana, et al.
Publicado: (2021)

A p38 MAPK-Mediated Alteration of COX-2/PGE(2) Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging
por: Yu, Kyung-Rok, et al.
Publicado: (2014)

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
por: de Oliveira, Antonio Carlos Pinheiro, et al.
Publicado: (2016)

Bridelia ferruginea Produces Antineuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling
por: Olajide, Olumayokun A., et al.
Publicado: (2012)

Aconitine Induces TRPV2-Mediated Ca(2+) Influx through the p38 MAPK Signal and Promotes Cardiomyocyte Apoptosis
por: Yang, Chunai, et al.
Publicado: (2021)

Correction: A p38 MAPK-Mediated Alteration of COX-2/PGE(2) Regulates Immunomodulatory Properties in Human Mesenchymal Stem Cell Aging
Publicado: (2014)

Revisiting p38 Mitogen-Activated Protein Kinases (MAPK) in Inflammatory Arthritis: A Narrative of the Emergence of MAPK-Activated Protein Kinase Inhibitors (MK2i)
por: Ganguly, Payal, et al.
Publicado: (2023)

Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells
por: Lynch, Katherine D., et al.
Publicado: (2023)

Induction of oxidative metabolism by the p38α/MK2 pathway
por: Trempolec, Natalia, et al.
Publicado: (2017)

Resveratrol potently reduces prostaglandin E(2 )production and free radical formation in lipopolysaccharide-activated primary rat microglia
por: Candelario-Jalil, Eduardo, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_ugqoprjb1t68p49ofgs7vscane