The effects of thioamide backbone substitution on protein stability: a study in α-helical, β-sheet, and polyproline II helical contexts

Thioamides are single atom substitutions of the peptide bond that serve as versatile probes of protein structure. Effective use of thioamides requires a robust understanding of the impact that the substitution has on a protein of interest. However, the thermodynamic effects of thioamide incorporatio...

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Detalles Bibliográficos
Autores principales: Walters, Christopher R., Szantai-Kis, D. Miklos, Zhang, Yitao, Reinert, Zachary E., Horne, W. Seth, Chenoweth, David M., Petersson, E. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428018/
https://www.ncbi.nlm.nih.gov/pubmed/28553525
http://dx.doi.org/10.1039/c6sc05580j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428018/
https://www.ncbi.nlm.nih.gov/pubmed/28553525
http://dx.doi.org/10.1039/c6sc05580j

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