Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands

The ruthenium(ii) polypyridyl complexes (RPCs), [(phen)(2)Ru(tatpp)](2+) (3(2+)) and [(phen)(2)Ru(tatpp)Ru(phen)(2)](4+) (4(4+)) are shown to cleave DNA in cell-free studies in the presence of a mild reducing agent, i.e. glutathione (GSH), in a manner that is enhanced upon lowering the [O(2)]. React...

Descripción completa

Detalles Bibliográficos
Autores principales: Griffith, Cynthia, Dayoub, Adam S., Jaranatne, Thamara, Alatrash, Nagham, Mohamedi, Ali, Abayan, Kenneth, Breitbach, Zachary S., Armstrong, Daniel W., MacDonnell, Frederick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428021/
https://www.ncbi.nlm.nih.gov/pubmed/28553531
http://dx.doi.org/10.1039/c6sc04094b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428021/
https://www.ncbi.nlm.nih.gov/pubmed/28553531
http://dx.doi.org/10.1039/c6sc04094b

Ejemplares similares