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Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands
The ruthenium(ii) polypyridyl complexes (RPCs), [(phen)(2)Ru(tatpp)](2+) (3(2+)) and [(phen)(2)Ru(tatpp)Ru(phen)(2)](4+) (4(4+)) are shown to cleave DNA in cell-free studies in the presence of a mild reducing agent, i.e. glutathione (GSH), in a manner that is enhanced upon lowering the [O(2)]. React...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428021/ https://www.ncbi.nlm.nih.gov/pubmed/28553531 http://dx.doi.org/10.1039/c6sc04094b |