High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly dec...

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Detalles Bibliográficos
Autores principales: Kivelä, A. M., Huusko, J., Gurzeler, E., Laine, A., Dijkstra, M. H., Dragneva, G., Andersen, C. B. F., Moestrup, S. K., Ylä-Herttuala, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428218/
https://www.ncbi.nlm.nih.gov/pubmed/28341860
http://dx.doi.org/10.1038/s41598-017-00376-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428218/
https://www.ncbi.nlm.nih.gov/pubmed/28341860
http://dx.doi.org/10.1038/s41598-017-00376-5

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