Cargando…

High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy

Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could significantly dec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kivelä, A. M., Huusko, J., Gurzeler, E., Laine, A., Dijkstra, M. H., Dragneva, G., Andersen, C. B. F., Moestrup, S. K., Ylä-Herttuala, S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428218/ https://www.ncbi.nlm.nih.gov/pubmed/28341860 http://dx.doi.org/10.1038/s41598-017-00376-5

Ejemplares similares

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
por: Naumenko, Nikolay, et al.
Publicado: (2017)

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
por: Dijkstra, M. H., et al.
Publicado: (2014)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Long-term safety and efficacy of intramyocardial adenovirus-mediated VEGF-D(ΔNΔC) gene therapy eight-year follow-up of phase I KAT301 study
por: Leikas, Aleksi J., et al.
Publicado: (2021)

Left ventricular remodeling leads to heart failure in mice with cardiac‐specific overexpression of VEGF‐B(167): echocardiography and magnetic resonance imaging study
por: Lottonen‐Raikaslehto, Line, et al.
Publicado: (2017)

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice
por: Merentie, Mari, et al.
Publicado: (2018)

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
por: Gurzeler, Erika, et al.
Publicado: (2021)

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
por: Gallini, Radiosa, et al.
Publicado: (2016)

Novel Designed Proteolytically Resistant VEGF-B186R127S Promotes Angiogenesis in Mouse Heart by Recruiting Endothelial Progenitor Cells
por: Mallick, Rahul, et al.
Publicado: (2022)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Lipid accumulation, lipid oxidation, and low plasma levels of acquired antibodies against oxidized lipids associate with degeneration and rupture of the intracranial aneurysm wall
por: Frösen, Juhana, et al.
Publicado: (2013)

Adenoviral Gene Therapy Vectors in Clinical Use—Basic Aspects with a Special Reference to Replication-Competent Adenovirus Formation and Its Impact on Clinical Safety
por: Leikas, Aleksi J., et al.
Publicado: (2023)

Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice
por: Turunen, Mikko P., et al.
Publicado: (2014)

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice
por: Theelen, Thomas L., et al.
Publicado: (2015)

AAV8-mediated sVEGFR2 and sVEGFR3 gene therapy combined with chemotherapy reduces the growth and microvasculature of human ovarian cancer and prolongs the survival in mice
por: Kujala, Anni, et al.
Publicado: (2022)

The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
por: Tirronen, Annakaisa, et al.
Publicado: (2021)

COVID-19 adenovirus vector vaccine induces higher interferon and pro-inflammatory responses than mRNA vaccines in human PBMCs, macrophages and moDCs
por: Jiang, Miao, et al.
Publicado: (2023)

In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR(–/–)ApoB(100/100) mice
por: Blanco, Fabiana, et al.
Publicado: (2018)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
por: Sopo, Minna, et al.
Publicado: (2019)

High expression of Tie-2 predicts poor prognosis in primary high grade serous ovarian cancer
por: Sopo, Minna, et al.
Publicado: (2020)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma
por: Sallinen, H., et al.
Publicado: (2019)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice
por: Merentie, Mari, et al.
Publicado: (2015)

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors
por: Nousiainen, Alisa, et al.
Publicado: (2023)

Control of VEGF-A transcriptional programs by pausing and genomic compartmentalization
por: Kaikkonen, Minna U., et al.
Publicado: (2014)

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Nucleic Acid–Based Therapies for Atherosclerosis
por: Mäkinen, Petri, et al.
Publicado: (2020)

Novel RNAi-Based Therapies for Atherosclerosis
por: Ruotsalainen, Anna-Kaisa, et al.
Publicado: (2021)

Editorial: Vascularization for Regenerative Medicine
por: Banfi, Andrea, et al.
Publicado: (2018)

Effect of cold atmospheric plasma (CAP) on human adenoviruses is adenovirus type-dependent
por: Bunz, Oskar, et al.
Publicado: (2018)

Quantification of myocardial infarct area based on T(RAFFn) relaxation time maps - comparison with cardiovascular magnetic resonance late gadolinium enhancement, T(1ρ) and T(2) in vivo
por: Yla-Herttuala, Elias, et al.
Publicado: (2018)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review
por: Zurek, Michelle, et al.
Publicado: (2021)

Increasing the Efficacy of Oncolytic Adenovirus Vectors
por: Toth, Karoly, et al.
Publicado: (2010)

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI
por: Lindgren, Auni, et al.
Publicado: (2017)

Uptake of (68)gallium in atherosclerotic plaques in LDLR(-/-)ApoB(100/100 )mice
por: Silvola, Johanna MU, et al.
Publicado: (2011)

Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
por: Laham-Karam, Nihay, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_toe4fti3s2rg4c7q97jrp5otvp