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Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis

Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF. Relevant...

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Autores principales: Peng, Yun-Peng, Zhu, Xiao-Le, Yin, Ling-Di, Zhu, Yi, Wei, Ji-Shu, Wu, Jun-Li, Miao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428241/
https://www.ncbi.nlm.nih.gov/pubmed/28298641
http://dx.doi.org/10.1038/s41598-017-00311-8
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author Peng, Yun-Peng
Zhu, Xiao-Le
Yin, Ling-Di
Zhu, Yi
Wei, Ji-Shu
Wu, Jun-Li
Miao, Yi
author_facet Peng, Yun-Peng
Zhu, Xiao-Le
Yin, Ling-Di
Zhu, Yi
Wei, Ji-Shu
Wu, Jun-Li
Miao, Yi
author_sort Peng, Yun-Peng
collection PubMed
description Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF. Relevant articles published up to June 21, 2016 were identified via PubMed, EMBASE, Web of Science, and The Cochrane Library. Studies that examined the risk factors of POPF following DP were enrolled. 20 articles (2070 patients) were finally included in this study. The pooled data suggested that patients with soft pancreas, higher Body Mass Index (BMI), blood transfusion, elevated intraoperative blood loss, and longer operative time had a decreased risk for POPF. However, age, gender, malignant pathology, types of stump closure, octreotide therapy, history of diabetes and chronic pancreatitis, splenectomy, multiorgan resection, main duct ligation, preoperative serum albumin levels, PGA felt wrapping, and extended lymphadenectomy could not be regarded as risk factors for POPF. Our analytic data demonstrated that pancreas texture, BMI, blood transfusion, intraoperative blood loss, and operative time were clinical predictor for POPF. This study may assist surgeons to screen patients with high risk of POPF and select appropriate treatment measures.
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spelling pubmed-54282412017-05-15 Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis Peng, Yun-Peng Zhu, Xiao-Le Yin, Ling-Di Zhu, Yi Wei, Ji-Shu Wu, Jun-Li Miao, Yi Sci Rep Article Postoperative pancreatic fistula (POPF) is a common complication following distal pancreatectomy (DP). However, the risk factors of this complication in patients after DP still remain controversial. The aim of our study is to estimate the association between potential risk factors and POPF. Relevant articles published up to June 21, 2016 were identified via PubMed, EMBASE, Web of Science, and The Cochrane Library. Studies that examined the risk factors of POPF following DP were enrolled. 20 articles (2070 patients) were finally included in this study. The pooled data suggested that patients with soft pancreas, higher Body Mass Index (BMI), blood transfusion, elevated intraoperative blood loss, and longer operative time had a decreased risk for POPF. However, age, gender, malignant pathology, types of stump closure, octreotide therapy, history of diabetes and chronic pancreatitis, splenectomy, multiorgan resection, main duct ligation, preoperative serum albumin levels, PGA felt wrapping, and extended lymphadenectomy could not be regarded as risk factors for POPF. Our analytic data demonstrated that pancreas texture, BMI, blood transfusion, intraoperative blood loss, and operative time were clinical predictor for POPF. This study may assist surgeons to screen patients with high risk of POPF and select appropriate treatment measures. Nature Publishing Group UK 2017-03-15 /pmc/articles/PMC5428241/ /pubmed/28298641 http://dx.doi.org/10.1038/s41598-017-00311-8 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Peng, Yun-Peng
Zhu, Xiao-Le
Yin, Ling-Di
Zhu, Yi
Wei, Ji-Shu
Wu, Jun-Li
Miao, Yi
Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_full Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_fullStr Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_full_unstemmed Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_short Risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
title_sort risk factors of postoperative pancreatic fistula in patients after distal pancreatectomy: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428241/
https://www.ncbi.nlm.nih.gov/pubmed/28298641
http://dx.doi.org/10.1038/s41598-017-00311-8
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