Relationship between somatic mosaicism of Pax6 mutation and variable developmental eye abnormalities—an analysis of CRISPR genome-edited mouse embryos

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas) system is a rapid gene-targeting technology that does not require embryonic stem cells. To demonstrate dosage effects of the Pax6 gene on eye formation, we generated Pax6-deficient mice with the CRI...

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Detalles Bibliográficos
Autores principales: Yasue, Akihiro, Kono, Hitomi, Habuta, Munenori, Bando, Tetsuya, Sato, Keita, Inoue, Junji, Oyadomari, Seiichi, Noji, Sumihare, Tanaka, Eiji, Ohuchi, Hideyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428340/
https://www.ncbi.nlm.nih.gov/pubmed/28246397
http://dx.doi.org/10.1038/s41598-017-00088-w

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