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Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck

Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral pro...

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Autores principales: Dong, Jian-Yong, Ning, Jie-Xin, Li, Kai, Liu, Chao, Wang, Xu-Xia, Li, Rong-Hui, Yue, Lin-Lin, Huang, Ying-Ying, Liu, Shao-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428440/
https://www.ncbi.nlm.nih.gov/pubmed/28336941
http://dx.doi.org/10.1038/s41598-017-00495-z
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author Dong, Jian-Yong
Ning, Jie-Xin
Li, Kai
Liu, Chao
Wang, Xu-Xia
Li, Rong-Hui
Yue, Lin-Lin
Huang, Ying-Ying
Liu, Shao-Hua
author_facet Dong, Jian-Yong
Ning, Jie-Xin
Li, Kai
Liu, Chao
Wang, Xu-Xia
Li, Rong-Hui
Yue, Lin-Lin
Huang, Ying-Ying
Liu, Shao-Hua
author_sort Dong, Jian-Yong
collection PubMed
description Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2.0 mg/kg/day. We evaluated the therapeutic responses 6 months after treatment and the end of treatment, which were categorized into four grades. The type and location of the lesions and the infant age at treatment initiation were analysed. The clinical response rate (III + IV) was 91.72% at 6 months after treatment and 97.63% at the end of treatment. The average treatment duration was 9.99 (2–24) months. The group aged 4–6 months exhibited a greater therapeutic response rate (98.48%). The treatment duration was shorter (9.52 months) for mixed-type IHs. Better therapeutic responses were observed for IHs located around the parotid, periorbital, cheek, and neck regions and for multiple IH lesions. Our study indicated that propranolol is effective for IHs affecting the head and neck. The age at treatment initiation and the location of the lesions had a significant effect on the therapeutic response, whereas the lesion type might affect the treatment duration.
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spelling pubmed-54284402017-05-15 Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck Dong, Jian-Yong Ning, Jie-Xin Li, Kai Liu, Chao Wang, Xu-Xia Li, Rong-Hui Yue, Lin-Lin Huang, Ying-Ying Liu, Shao-Hua Sci Rep Article Infantile haemangiomas (IHs) are the most common congenital vascular tumours of infancy. Propranolol has been demonstrated to be effective for IHs; however, the factors affecting its therapeutic effect remain unknown. We enrolled 169 infants with IHs of the head and neck region treated with oral propranolol at a dose of 2.0 mg/kg/day. We evaluated the therapeutic responses 6 months after treatment and the end of treatment, which were categorized into four grades. The type and location of the lesions and the infant age at treatment initiation were analysed. The clinical response rate (III + IV) was 91.72% at 6 months after treatment and 97.63% at the end of treatment. The average treatment duration was 9.99 (2–24) months. The group aged 4–6 months exhibited a greater therapeutic response rate (98.48%). The treatment duration was shorter (9.52 months) for mixed-type IHs. Better therapeutic responses were observed for IHs located around the parotid, periorbital, cheek, and neck regions and for multiple IH lesions. Our study indicated that propranolol is effective for IHs affecting the head and neck. The age at treatment initiation and the location of the lesions had a significant effect on the therapeutic response, whereas the lesion type might affect the treatment duration. Nature Publishing Group UK 2017-03-23 /pmc/articles/PMC5428440/ /pubmed/28336941 http://dx.doi.org/10.1038/s41598-017-00495-z Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Dong, Jian-Yong
Ning, Jie-Xin
Li, Kai
Liu, Chao
Wang, Xu-Xia
Li, Rong-Hui
Yue, Lin-Lin
Huang, Ying-Ying
Liu, Shao-Hua
Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_full Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_fullStr Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_full_unstemmed Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_short Analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
title_sort analysis of factors affecting the therapeutic effect of propranolol for infantile haemangioma of the head and neck
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428440/
https://www.ncbi.nlm.nih.gov/pubmed/28336941
http://dx.doi.org/10.1038/s41598-017-00495-z
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