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Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association
Devil facial tumour disease (DFTD) has decimated wild populations of Tasmanian devils (Sarcophilus harrisii) due to its ability to avoid immune detection and pass from host to host by biting. A small number of devils have been observed to spontaneously recover from the disease which is otherwise fat...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428454/ https://www.ncbi.nlm.nih.gov/pubmed/28341828 http://dx.doi.org/10.1038/s41598-017-00439-7 |
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author | Wright, Belinda Willet, Cali E. Hamede, Rodrigo Jones, Menna Belov, Katherine Wade, Claire M. |
author_facet | Wright, Belinda Willet, Cali E. Hamede, Rodrigo Jones, Menna Belov, Katherine Wade, Claire M. |
author_sort | Wright, Belinda |
collection | PubMed |
description | Devil facial tumour disease (DFTD) has decimated wild populations of Tasmanian devils (Sarcophilus harrisii) due to its ability to avoid immune detection and pass from host to host by biting. A small number of devils have been observed to spontaneously recover from the disease which is otherwise fatal. We have sequenced the genomes of these rare cases and compared them to the genomes of devils who succumbed to the disease. Genome-wide association, based on this limited sampling, highlighted two key genomic regions potentially associated with ability to survive DFTD. Following targeted genotyping in additional samples, both of these loci remain significantly different between cases and controls, with the PAX3 locus retaining significance at the 0.001 level, though genome-wide significance was not achieved. We propose that PAX3 may be involved in a regulatory pathway that influences the slowing of tumour growth and may allow more time for an immune response to be mounted in animals with regressed tumours. This provides an intriguing hypothesis for further research and could provide a novel route of treatment for this devastating disease. |
format | Online Article Text |
id | pubmed-5428454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-54284542017-05-15 Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association Wright, Belinda Willet, Cali E. Hamede, Rodrigo Jones, Menna Belov, Katherine Wade, Claire M. Sci Rep Article Devil facial tumour disease (DFTD) has decimated wild populations of Tasmanian devils (Sarcophilus harrisii) due to its ability to avoid immune detection and pass from host to host by biting. A small number of devils have been observed to spontaneously recover from the disease which is otherwise fatal. We have sequenced the genomes of these rare cases and compared them to the genomes of devils who succumbed to the disease. Genome-wide association, based on this limited sampling, highlighted two key genomic regions potentially associated with ability to survive DFTD. Following targeted genotyping in additional samples, both of these loci remain significantly different between cases and controls, with the PAX3 locus retaining significance at the 0.001 level, though genome-wide significance was not achieved. We propose that PAX3 may be involved in a regulatory pathway that influences the slowing of tumour growth and may allow more time for an immune response to be mounted in animals with regressed tumours. This provides an intriguing hypothesis for further research and could provide a novel route of treatment for this devastating disease. Nature Publishing Group UK 2017-03-24 /pmc/articles/PMC5428454/ /pubmed/28341828 http://dx.doi.org/10.1038/s41598-017-00439-7 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Wright, Belinda Willet, Cali E. Hamede, Rodrigo Jones, Menna Belov, Katherine Wade, Claire M. Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title | Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title_full | Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title_fullStr | Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title_full_unstemmed | Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title_short | Variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
title_sort | variants in the host genome may inhibit tumour growth in devil facial tumours: evidence from genome-wide association |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428454/ https://www.ncbi.nlm.nih.gov/pubmed/28341828 http://dx.doi.org/10.1038/s41598-017-00439-7 |
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