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Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis

It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune r...

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Autores principales: Yu, Zhi-Jian, Zeng, Lu, Luo, Xiang-Qian, Geng, Xiao-Rui, Xu, Rui, Chen, Kun, Yang, Gui, Luo, Xi, Liu, Zhi-Qiang, Liu, Zhi-Gang, Liu, Da-Bo, Yang, Ping-Chang, Li, Hua-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428505/
https://www.ncbi.nlm.nih.gov/pubmed/28373650
http://dx.doi.org/10.1038/s41598-017-00431-1
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author Yu, Zhi-Jian
Zeng, Lu
Luo, Xiang-Qian
Geng, Xiao-Rui
Xu, Rui
Chen, Kun
Yang, Gui
Luo, Xi
Liu, Zhi-Qiang
Liu, Zhi-Gang
Liu, Da-Bo
Yang, Ping-Chang
Li, Hua-Bin
author_facet Yu, Zhi-Jian
Zeng, Lu
Luo, Xiang-Qian
Geng, Xiao-Rui
Xu, Rui
Chen, Kun
Yang, Gui
Luo, Xi
Liu, Zhi-Qiang
Liu, Zhi-Gang
Liu, Da-Bo
Yang, Ping-Chang
Li, Hua-Bin
author_sort Yu, Zhi-Jian
collection PubMed
description It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3. The expression of miR-19a and IL-10 was significantly negatively correlated with each other in peripheral B cells of AR patients. Metabolites of VD3 formed a complex with retinoid acid receptor to repress the expression of miR-19a in B cells. We conclude that administration with VD3 promotes the effect of SIT on suppression of AR via repressing the expression of miR-19a in peripheral B cells.
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spelling pubmed-54285052017-05-15 Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis Yu, Zhi-Jian Zeng, Lu Luo, Xiang-Qian Geng, Xiao-Rui Xu, Rui Chen, Kun Yang, Gui Luo, Xi Liu, Zhi-Qiang Liu, Zhi-Gang Liu, Da-Bo Yang, Ping-Chang Li, Hua-Bin Sci Rep Article It is recognized that T helper 2 (Th2) polarization plays a critical role in a large number of immune disorders. Yet, the remedies for reconciling the established Th2 polarization are still limited currently. Published data indicate that micro RNA-17-92 cluster is associated with the skewed immune response; 25 vitamin D3 (VD3) can regulate multiple bioactivities in the body. This study tests a hypothesis that VD3 facilitates the effect of specific immunotherapy (SIT) on Th2 response. We observed that treatment with either SIT or VD3 alleviated AR symptoms as well as reduced serum levels of specific IgE and T helper (Th) 2 cytokines, suppressed miR-19a (one of the members of the miR-17-92 cluster) and increased IL-10 in peripheral B cells, which was further improved in those AR patients treated with both SIT and VD3. The expression of miR-19a and IL-10 was significantly negatively correlated with each other in peripheral B cells of AR patients. Metabolites of VD3 formed a complex with retinoid acid receptor to repress the expression of miR-19a in B cells. We conclude that administration with VD3 promotes the effect of SIT on suppression of AR via repressing the expression of miR-19a in peripheral B cells. Nature Publishing Group UK 2017-04-03 /pmc/articles/PMC5428505/ /pubmed/28373650 http://dx.doi.org/10.1038/s41598-017-00431-1 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Yu, Zhi-Jian
Zeng, Lu
Luo, Xiang-Qian
Geng, Xiao-Rui
Xu, Rui
Chen, Kun
Yang, Gui
Luo, Xi
Liu, Zhi-Qiang
Liu, Zhi-Gang
Liu, Da-Bo
Yang, Ping-Chang
Li, Hua-Bin
Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_full Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_fullStr Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_full_unstemmed Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_short Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis
title_sort vitamin d3 inhibits micro rna-17-92 to promote specific immunotherapy in allergic rhinitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428505/
https://www.ncbi.nlm.nih.gov/pubmed/28373650
http://dx.doi.org/10.1038/s41598-017-00431-1
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