Abnormal expression of ATP1A1 and ATP1A2 in breast cancer

Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expre...

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Detalles Bibliográficos
Autores principales: Bogdanov, Alexey, Moiseenko, Fedor, Dubina, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428514/
https://www.ncbi.nlm.nih.gov/pubmed/28529692
http://dx.doi.org/10.12688/f1000research.10481.1
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author Bogdanov, Alexey
Moiseenko, Fedor
Dubina, Michael
author_facet Bogdanov, Alexey
Moiseenko, Fedor
Dubina, Michael
author_sort Bogdanov, Alexey
collection PubMed
description Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expression profiling (NCBI GEO database, accession GSE65194), focusing on Na (+)/K (+)-ATPase coding genes. We found overexpression of the ATP1A1 and down-regulation of the ATP1A2. We expect that our research could help to improve the understanding of predictive and prognostic features of breast cancer.
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spelling pubmed-54285142017-05-18 Abnormal expression of ATP1A1 and ATP1A2 in breast cancer Bogdanov, Alexey Moiseenko, Fedor Dubina, Michael F1000Res Research Note Breast cancer is the first in incidence and the second in death among all solid tumors occurring in women. The identification of molecular genetic abnormalities in breast cancer is important to improve the results of treatment. In the present study, we analyzed microarray data of breast cancer expression profiling (NCBI GEO database, accession GSE65194), focusing on Na (+)/K (+)-ATPase coding genes. We found overexpression of the ATP1A1 and down-regulation of the ATP1A2. We expect that our research could help to improve the understanding of predictive and prognostic features of breast cancer. F1000Research 2017-01-05 /pmc/articles/PMC5428514/ /pubmed/28529692 http://dx.doi.org/10.12688/f1000research.10481.1 Text en Copyright: © 2017 Bogdanov A et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Bogdanov, Alexey
Moiseenko, Fedor
Dubina, Michael
Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title_full Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title_fullStr Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title_full_unstemmed Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title_short Abnormal expression of ATP1A1 and ATP1A2 in breast cancer
title_sort abnormal expression of atp1a1 and atp1a2 in breast cancer
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428514/
https://www.ncbi.nlm.nih.gov/pubmed/28529692
http://dx.doi.org/10.12688/f1000research.10481.1
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AT dubinamichael abnormalexpressionofatp1a1andatp1a2inbreastcancer

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