Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selected for their robust and reproducible inhibitory effects with...

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Detalles Bibliográficos
Autores principales: Parnell, Euan, McElroy, Stuart P., Wiejak, Jolanta, Baillie, Gemma L., Porter, Alison, Adams, David R., Rehmann, Holger, Smith, Brian O., Yarwood, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428521/
https://www.ncbi.nlm.nih.gov/pubmed/28331191
http://dx.doi.org/10.1038/s41598-017-00455-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428521/
https://www.ncbi.nlm.nih.gov/pubmed/28331191
http://dx.doi.org/10.1038/s41598-017-00455-7

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