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Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
Screening of a carefully selected library of 5,195 small molecules identified 34 hit compounds that interact with the regulatory cyclic nucleotide-binding domain (CNB) of the cAMP sensor, EPAC1. Two of these hits (I942 and I178) were selected for their robust and reproducible inhibitory effects with...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428521/ https://www.ncbi.nlm.nih.gov/pubmed/28331191 http://dx.doi.org/10.1038/s41598-017-00455-7 |