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Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function
Although transmembrane helix-helix interactions must be strong enough to drive folding, they must still permit the inter-helix movements associated with conformational change. Interactions between the outermost M4 and adjacent M1 and M3 α-helices of pentameric ligand-gated ion channels have been imp...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428567/ https://www.ncbi.nlm.nih.gov/pubmed/28348412 http://dx.doi.org/10.1038/s41598-017-00573-2 |