Cargando…

The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study

The study was designed to reveal the genetic relationship of lymphotoxin-α (LTA) polymorphisms with risk of ankylosing spondylitis (AS) in Chinese Han population. LTA polymorphisms were genotyped by polymerase chain reaction-direct sequencing (PCR-DS) in 138 AS patients and 141 healthy controls. The...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Bei, Qi, Xiangbei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428590/
https://www.ncbi.nlm.nih.gov/pubmed/28489756
http://dx.doi.org/10.1097/MD.0000000000006796
_version_ 1783235854095876096
author Jia, Bei
Qi, Xiangbei
author_facet Jia, Bei
Qi, Xiangbei
author_sort Jia, Bei
collection PubMed
description The study was designed to reveal the genetic relationship of lymphotoxin-α (LTA) polymorphisms with risk of ankylosing spondylitis (AS) in Chinese Han population. LTA polymorphisms were genotyped by polymerase chain reaction-direct sequencing (PCR-DS) in 138 AS patients and 141 healthy controls. The genotype distribution in control group was checked the status of Hardy–Weinberg equilibrium (HWE). Odds ratio (OR) with 95% confidence interval (95%CI) calculated by χ(2) test was used to show effects of LTA polymorphisms on AS risk. Logistic regressive analysis was used to calculate the adjusted OR values. Additionally, the linkage disequilibrium of LTA polymorphisms was examined by Haploview. G allele of rs909253 was significantly higher frequency in AS patients (P = .02), which was associated with the increased risk of AS (OR = 1.53, 95%CI = 1.07–2.18). The carriages of GG genotype in rs909253 showed a high risk of AS occurrence, compared with AA genotype carriers (OR = 2.46, 95%CI = 1.13–5.35). Multivariate analysis demonstrated that the G allele (OR = 1.52, 95%CI = 1.05–2.15) and GG genotype (OR = 2.36, 95%CI = 1.06–5.24) of rs909253 were still positively associated with AS susceptibility. However, there was no significant association between AS risk and rs2239704 or rs2229094. LTA rs909253 polymorphism contributes to the occurrence of AS.
format Online
Article
Text
id pubmed-5428590
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-54285902017-05-17 The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study Jia, Bei Qi, Xiangbei Medicine (Baltimore) 7100 The study was designed to reveal the genetic relationship of lymphotoxin-α (LTA) polymorphisms with risk of ankylosing spondylitis (AS) in Chinese Han population. LTA polymorphisms were genotyped by polymerase chain reaction-direct sequencing (PCR-DS) in 138 AS patients and 141 healthy controls. The genotype distribution in control group was checked the status of Hardy–Weinberg equilibrium (HWE). Odds ratio (OR) with 95% confidence interval (95%CI) calculated by χ(2) test was used to show effects of LTA polymorphisms on AS risk. Logistic regressive analysis was used to calculate the adjusted OR values. Additionally, the linkage disequilibrium of LTA polymorphisms was examined by Haploview. G allele of rs909253 was significantly higher frequency in AS patients (P = .02), which was associated with the increased risk of AS (OR = 1.53, 95%CI = 1.07–2.18). The carriages of GG genotype in rs909253 showed a high risk of AS occurrence, compared with AA genotype carriers (OR = 2.46, 95%CI = 1.13–5.35). Multivariate analysis demonstrated that the G allele (OR = 1.52, 95%CI = 1.05–2.15) and GG genotype (OR = 2.36, 95%CI = 1.06–5.24) of rs909253 were still positively associated with AS susceptibility. However, there was no significant association between AS risk and rs2239704 or rs2229094. LTA rs909253 polymorphism contributes to the occurrence of AS. Wolters Kluwer Health 2017-05-12 /pmc/articles/PMC5428590/ /pubmed/28489756 http://dx.doi.org/10.1097/MD.0000000000006796 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 7100
Jia, Bei
Qi, Xiangbei
The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title_full The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title_fullStr The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title_full_unstemmed The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title_short The genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in Chinese group: A case-control study
title_sort genetic association between polymorphisms in lymphotoxin-α gene and ankylosing spondylitis susceptibility in chinese group: a case-control study
topic 7100
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428590/
https://www.ncbi.nlm.nih.gov/pubmed/28489756
http://dx.doi.org/10.1097/MD.0000000000006796
work_keys_str_mv AT jiabei thegeneticassociationbetweenpolymorphismsinlymphotoxinageneandankylosingspondylitissusceptibilityinchinesegroupacasecontrolstudy
AT qixiangbei thegeneticassociationbetweenpolymorphismsinlymphotoxinageneandankylosingspondylitissusceptibilityinchinesegroupacasecontrolstudy
AT jiabei geneticassociationbetweenpolymorphismsinlymphotoxinageneandankylosingspondylitissusceptibilityinchinesegroupacasecontrolstudy
AT qixiangbei geneticassociationbetweenpolymorphismsinlymphotoxinageneandankylosingspondylitissusceptibilityinchinesegroupacasecontrolstudy