E(μ) and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells

Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene cluster: the...

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Detalles Bibliográficos
Autores principales: Saintamand, A., Vincent-Fabert, C., Marquet, M., Ghazzaui, N., Magnone, V., Pinaud, E., Cogné, M., Denizot, Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428668/
https://www.ncbi.nlm.nih.gov/pubmed/28348365
http://dx.doi.org/10.1038/s41598-017-00575-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428668/
https://www.ncbi.nlm.nih.gov/pubmed/28348365
http://dx.doi.org/10.1038/s41598-017-00575-0

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