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E(μ) and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells
Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene cluster: the...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428668/ https://www.ncbi.nlm.nih.gov/pubmed/28348365 http://dx.doi.org/10.1038/s41598-017-00575-0 |