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Reconstruction of Large-scale Defects with a Novel Hybrid Scaffold Made from Poly(L-lactic acid)/Nanohydroxyapatite/Alendronate-loaded Chitosan Microsphere: in vitro and in vivo Studies

A chitosan-based microsphere delivery system has been fabricated for controlled release of alendronate (AL). The present study aimed to incorporate the chitosan/hydroxyapatite microspheres-loaded with AL (CH/nHA-AL) into poly(L-lactic acid)/nanohydroxyapatite (PLLA/nHA) matrix to prepare a novel mic...

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Detalles Bibliográficos
Autores principales:	Wu, Hongwei, Lei, Pengfei, Liu, Gengyan, Shrike Zhang, Yu, Yang, Jingzhou, Zhang, Longbo, Xie, Jie, Niu, Wanting, Liu, Hua, Ruan, Jianming, Hu, Yihe, Zhang, Chaoyue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428684/ https://www.ncbi.nlm.nih.gov/pubmed/28337023 http://dx.doi.org/10.1038/s41598-017-00506-z

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