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Bisphenol S negatively affects the meotic maturation of pig oocytes

Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effe...

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Autores principales: Žalmanová, Tereza, Hošková, Kristýna, Nevoral, Jan, Adámková, Kateřina, Kott, Tomáš, Šulc, Miloslav, Kotíková, Zora, Prokešová, Šárka, Jílek, František, Králíčková, Milena, Petr, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428703/
https://www.ncbi.nlm.nih.gov/pubmed/28352085
http://dx.doi.org/10.1038/s41598-017-00570-5
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author Žalmanová, Tereza
Hošková, Kristýna
Nevoral, Jan
Adámková, Kateřina
Kott, Tomáš
Šulc, Miloslav
Kotíková, Zora
Prokešová, Šárka
Jílek, František
Králíčková, Milena
Petr, Jaroslav
author_facet Žalmanová, Tereza
Hošková, Kristýna
Nevoral, Jan
Adámková, Kateřina
Kott, Tomáš
Šulc, Miloslav
Kotíková, Zora
Prokešová, Šárka
Jílek, František
Králíčková, Milena
Petr, Jaroslav
author_sort Žalmanová, Tereza
collection PubMed
description Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced.
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spelling pubmed-54287032017-05-15 Bisphenol S negatively affects the meotic maturation of pig oocytes Žalmanová, Tereza Hošková, Kristýna Nevoral, Jan Adámková, Kateřina Kott, Tomáš Šulc, Miloslav Kotíková, Zora Prokešová, Šárka Jílek, František Králíčková, Milena Petr, Jaroslav Sci Rep Article Bisphenol A (BPA), a chemical component of plastics, is a widely distributed environmental pollutant and contaminant of water, air, and food that negatively impacts human health. Concerns regarding BPA have led to the use of BPA-free alternatives, one of which is bisphenol S (BPS). However, the effects of BPS are not well characterized, and its specific effects on reproduction and fertility remain unknown. It is therefore necessary to evaluate any effects of BPS on mammalian oocytes. The present study is the first to demonstrate the markedly negative effects of BPS on pig oocyte maturation in vitro, even at doses lower than those humans are exposed to in the environment. Our results demonstrate (1) an effect of BPS on the course of the meiotic cell cycle; (2) the failure of tubulin fibre formation, which controls proper chromosome movement; (3) changes in the supply of maternal mRNA; (4) changes in the protein amounts and distribution of oestrogen receptors α and β and of aromatase; and (5) disrupted cumulus cell expansion. Thus, these results confirm that BPS is an example of regrettable substitution because this substance exerts similar or even worse negative effects than those of the material it replaced. Nature Publishing Group UK 2017-03-28 /pmc/articles/PMC5428703/ /pubmed/28352085 http://dx.doi.org/10.1038/s41598-017-00570-5 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Žalmanová, Tereza
Hošková, Kristýna
Nevoral, Jan
Adámková, Kateřina
Kott, Tomáš
Šulc, Miloslav
Kotíková, Zora
Prokešová, Šárka
Jílek, František
Králíčková, Milena
Petr, Jaroslav
Bisphenol S negatively affects the meotic maturation of pig oocytes
title Bisphenol S negatively affects the meotic maturation of pig oocytes
title_full Bisphenol S negatively affects the meotic maturation of pig oocytes
title_fullStr Bisphenol S negatively affects the meotic maturation of pig oocytes
title_full_unstemmed Bisphenol S negatively affects the meotic maturation of pig oocytes
title_short Bisphenol S negatively affects the meotic maturation of pig oocytes
title_sort bisphenol s negatively affects the meotic maturation of pig oocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428703/
https://www.ncbi.nlm.nih.gov/pubmed/28352085
http://dx.doi.org/10.1038/s41598-017-00570-5
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