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Neural basis of negativity bias in the perception of ambiguous facial expression

Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneously accessi...

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Autores principales: Ito, Takehito, Yokokawa, Keita, Yahata, Noriaki, Isato, Ayako, Suhara, Tetsuya, Yamada, Makiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428736/
https://www.ncbi.nlm.nih.gov/pubmed/28341827
http://dx.doi.org/10.1038/s41598-017-00502-3
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author Ito, Takehito
Yokokawa, Keita
Yahata, Noriaki
Isato, Ayako
Suhara, Tetsuya
Yamada, Makiko
author_facet Ito, Takehito
Yokokawa, Keita
Yahata, Noriaki
Isato, Ayako
Suhara, Tetsuya
Yamada, Makiko
author_sort Ito, Takehito
collection PubMed
description Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneously accessible, to examine neural activation during perceptual decision-making in healthy participants. The negativity bias was positively correlated with the activity of the bilateral pregenual anterior cingulate cortex (pgACC) when ambiguous faces were perceived as sad versus happy. Additionally, the strength of the functional connectivity between the bilateral pgACC and the right dorsal ACC (dACC)/right thalamus was positively correlated with hopelessness, one of the core characteristics of depression. Given the role of the pgACC as a major site of depressive affect and the roles of the dACC and thalamus in conflict monitoring and vigilance, respectively, our results reveal valid and important neuroanatomical correlates of the association between negativity bias and hopelessness in the healthy individuals.
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spelling pubmed-54287362017-05-15 Neural basis of negativity bias in the perception of ambiguous facial expression Ito, Takehito Yokokawa, Keita Yahata, Noriaki Isato, Ayako Suhara, Tetsuya Yamada, Makiko Sci Rep Article Negativity bias, which describes the tendency to interpret ambiguous stimuli or events as negative, is often observed in patients with depression and may prevent psychological well-being. Here, we used ambiguous facial stimuli, with negative (sad) and positive (happy) emotions simultaneously accessible, to examine neural activation during perceptual decision-making in healthy participants. The negativity bias was positively correlated with the activity of the bilateral pregenual anterior cingulate cortex (pgACC) when ambiguous faces were perceived as sad versus happy. Additionally, the strength of the functional connectivity between the bilateral pgACC and the right dorsal ACC (dACC)/right thalamus was positively correlated with hopelessness, one of the core characteristics of depression. Given the role of the pgACC as a major site of depressive affect and the roles of the dACC and thalamus in conflict monitoring and vigilance, respectively, our results reveal valid and important neuroanatomical correlates of the association between negativity bias and hopelessness in the healthy individuals. Nature Publishing Group UK 2017-03-24 /pmc/articles/PMC5428736/ /pubmed/28341827 http://dx.doi.org/10.1038/s41598-017-00502-3 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Ito, Takehito
Yokokawa, Keita
Yahata, Noriaki
Isato, Ayako
Suhara, Tetsuya
Yamada, Makiko
Neural basis of negativity bias in the perception of ambiguous facial expression
title Neural basis of negativity bias in the perception of ambiguous facial expression
title_full Neural basis of negativity bias in the perception of ambiguous facial expression
title_fullStr Neural basis of negativity bias in the perception of ambiguous facial expression
title_full_unstemmed Neural basis of negativity bias in the perception of ambiguous facial expression
title_short Neural basis of negativity bias in the perception of ambiguous facial expression
title_sort neural basis of negativity bias in the perception of ambiguous facial expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428736/
https://www.ncbi.nlm.nih.gov/pubmed/28341827
http://dx.doi.org/10.1038/s41598-017-00502-3
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