Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines

Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recu...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Yu, Yang, Liu, Wei, Li, Zhi, Wei, Zhongqing, Jiang, Rongjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428793/
https://www.ncbi.nlm.nih.gov/pubmed/28507979
http://dx.doi.org/10.2147/RRU.S118966
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author Yang, Jian
Yu, Yang
Liu, Wei
Li, Zhi
Wei, Zhongqing
Jiang, Rongjiang
author_facet Yang, Jian
Yu, Yang
Liu, Wei
Li, Zhi
Wei, Zhongqing
Jiang, Rongjiang
author_sort Yang, Jian
collection PubMed
description Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recurrent prostate cancer cells after docetaxel treatment have higher levels of microtubule-associated protein tau. In vitro, inactivation of tau by gene knockdown suppressed cell proliferation and sensitized docetaxel cytotoxicity. Also, our results demonstrated that the PI3K/Akt/mTOR pathway was upregulated in DU145 docetaxel-resistant cells compared with the DU145-naïve cells. Thus, targeting tau protein and PI3K/Akt/mTOR pathway are promising strategies to enhance docetaxel response for the treatment of prostate cancer.
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spelling pubmed-54287932017-05-15 Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines Yang, Jian Yu, Yang Liu, Wei Li, Zhi Wei, Zhongqing Jiang, Rongjiang Res Rep Urol Original Research Tau, a microtubule-associated protein, has been investigated primarily in neurons. Recently, tau has been explored to be associated with increased drug resistance in various kinds of cancers. We found that the tau was expressed in prostate cancer cell lines DU145 and PC-3. We also reported that recurrent prostate cancer cells after docetaxel treatment have higher levels of microtubule-associated protein tau. In vitro, inactivation of tau by gene knockdown suppressed cell proliferation and sensitized docetaxel cytotoxicity. Also, our results demonstrated that the PI3K/Akt/mTOR pathway was upregulated in DU145 docetaxel-resistant cells compared with the DU145-naïve cells. Thus, targeting tau protein and PI3K/Akt/mTOR pathway are promising strategies to enhance docetaxel response for the treatment of prostate cancer. Dove Medical Press 2017-05-08 /pmc/articles/PMC5428793/ /pubmed/28507979 http://dx.doi.org/10.2147/RRU.S118966 Text en © 2017 Yang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Yang, Jian
Yu, Yang
Liu, Wei
Li, Zhi
Wei, Zhongqing
Jiang, Rongjiang
Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title_full Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title_fullStr Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title_full_unstemmed Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title_short Microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
title_sort microtubule-associated protein tau is associated with the resistance to docetaxel in prostate cancer cell lines
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428793/
https://www.ncbi.nlm.nih.gov/pubmed/28507979
http://dx.doi.org/10.2147/RRU.S118966
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