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Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico mode...

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Detalles Bibliográficos
Autores principales: Polak, Marta E., Ung, Chuin Ying, Masapust, Joanna, Freeman, Tom C., Ardern-Jones, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428800/
https://www.ncbi.nlm.nih.gov/pubmed/28386100
http://dx.doi.org/10.1038/s41598-017-00651-5