Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels

Recombinant TWIK2 channels produce weak basal background K(+) currents. Current amplitudes depend on the animal species the channels have been isolated from and on the heterologous system used for their re-expression. Here we show that this variability is due to a unique cellular trafficking. We ide...

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Detalles Bibliográficos
Autores principales: Bobak, Nicole, Feliciangeli, Sylvain, Chen, Cheng-Chang, Ben Soussia, Ismail, Bittner, Stefan, Pagnotta, Sophie, Ruck, Tobias, Biel, Martin, Wahl-Schott, Christian, Grimm, Christian, Meuth, Sven G., Lesage, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428834/
https://www.ncbi.nlm.nih.gov/pubmed/28381826
http://dx.doi.org/10.1038/s41598-017-00640-8

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