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Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma
Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free sur...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428928/ https://www.ncbi.nlm.nih.gov/pubmed/28498842 http://dx.doi.org/10.1371/journal.pone.0177520 |
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author | Zhang, Hongwei Lu, Jiaqi Lu, Yingying Zhou, Jiayi Wang, Zehua Liu, Haiou Xu, Congjian |
author_facet | Zhang, Hongwei Lu, Jiaqi Lu, Yingying Zhou, Jiayi Wang, Zehua Liu, Haiou Xu, Congjian |
author_sort | Zhang, Hongwei |
collection | PubMed |
description | Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell’s concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS (P = 0.006) and OS (P = 0.019). The SIS had a good discrimination ability for the predictive PFS (c-index = 0.712) and OS (c-index = 0.722). We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical management. |
format | Online Article Text |
id | pubmed-5428928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54289282017-05-26 Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma Zhang, Hongwei Lu, Jiaqi Lu, Yingying Zhou, Jiayi Wang, Zehua Liu, Haiou Xu, Congjian PLoS One Research Article Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective review was performed in 155 patients with OCCC undergoing primary debulking and chemotherapy at a single institute between 1995 and 2010. Cox regression models were fitted to analyze the effect of prognostic factors on PFS and OS. Harrell’s concordance index was calculated to assess predictive accuracy. The SIS consisting of serum albumin and NLR was retained as an independent indicator adjusting for traditional clinicopathological features. A high SIS was significantly associated with aggressive tumor behavior, platinum resistance, and served as an independent predictor of reduced PFS (P = 0.006) and OS (P = 0.019). The SIS had a good discrimination ability for the predictive PFS (c-index = 0.712) and OS (c-index = 0.722). We have developed a system inflammation score for predicting prognosis of OCCC patients, which may help stratify patients for postsurgical management. Public Library of Science 2017-05-12 /pmc/articles/PMC5428928/ /pubmed/28498842 http://dx.doi.org/10.1371/journal.pone.0177520 Text en © 2017 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhang, Hongwei Lu, Jiaqi Lu, Yingying Zhou, Jiayi Wang, Zehua Liu, Haiou Xu, Congjian Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title | Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title_full | Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title_fullStr | Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title_full_unstemmed | Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title_short | Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
title_sort | prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428928/ https://www.ncbi.nlm.nih.gov/pubmed/28498842 http://dx.doi.org/10.1371/journal.pone.0177520 |
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