Human osteopontin: Potential clinical applications in cancer (Review)

Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in seve...

Descripción completa

Detalles Bibliográficos
Autores principales: Hao, Chengcheng, Cui, Yuxin, Owen, Sionen, Li, Wenbin, Cheng, Shan, Jiang, Wen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428945/
https://www.ncbi.nlm.nih.gov/pubmed/28440483
http://dx.doi.org/10.3892/ijmm.2017.2964
_version_ 1783235936304234496
author Hao, Chengcheng
Cui, Yuxin
Owen, Sionen
Li, Wenbin
Cheng, Shan
Jiang, Wen G.
author_facet Hao, Chengcheng
Cui, Yuxin
Owen, Sionen
Li, Wenbin
Cheng, Shan
Jiang, Wen G.
author_sort Hao, Chengcheng
collection PubMed
description Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target.
format Online
Article
Text
id pubmed-5428945
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-54289452017-05-15 Human osteopontin: Potential clinical applications in cancer (Review) Hao, Chengcheng Cui, Yuxin Owen, Sionen Li, Wenbin Cheng, Shan Jiang, Wen G. Int J Mol Med Articles Human osteopontin (OPN) is a glycosylated phosphoprotein which is expressed in a variety of tissues in the body. In recent years, accumulating evidence has indicated that the aberrant expression of OPN is closely associated with tumourigensis, progression and most prominently with metastasis in several tumour types. In this review, we present the current knowledge on the expression profiles of OPN and its main splice variants in human cancers, as well as the potential implications in patient outcome. We also discuss its putative clinical application as a cancer biomarker and as a therapeutic target. D.A. Spandidos 2017-06 2017-04-21 /pmc/articles/PMC5428945/ /pubmed/28440483 http://dx.doi.org/10.3892/ijmm.2017.2964 Text en Copyright: © Hao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Hao, Chengcheng
Cui, Yuxin
Owen, Sionen
Li, Wenbin
Cheng, Shan
Jiang, Wen G.
Human osteopontin: Potential clinical applications in cancer (Review)
title Human osteopontin: Potential clinical applications in cancer (Review)
title_full Human osteopontin: Potential clinical applications in cancer (Review)
title_fullStr Human osteopontin: Potential clinical applications in cancer (Review)
title_full_unstemmed Human osteopontin: Potential clinical applications in cancer (Review)
title_short Human osteopontin: Potential clinical applications in cancer (Review)
title_sort human osteopontin: potential clinical applications in cancer (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428945/
https://www.ncbi.nlm.nih.gov/pubmed/28440483
http://dx.doi.org/10.3892/ijmm.2017.2964
work_keys_str_mv AT haochengcheng humanosteopontinpotentialclinicalapplicationsincancerreview
AT cuiyuxin humanosteopontinpotentialclinicalapplicationsincancerreview
AT owensionen humanosteopontinpotentialclinicalapplicationsincancerreview
AT liwenbin humanosteopontinpotentialclinicalapplicationsincancerreview
AT chengshan humanosteopontinpotentialclinicalapplicationsincancerreview
AT jiangweng humanosteopontinpotentialclinicalapplicationsincancerreview

Ejemplares similares