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Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Ca...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428970/ https://www.ncbi.nlm.nih.gov/pubmed/28498861 http://dx.doi.org/10.1371/journal.pone.0177660 |
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author | Ichikawa, Yasuhiro Zemljic-Harpf, Alice E. Zhang, Zheng McKirnan, M. Dan Manso, Ana Maria Ross, Robert S. Hammond, H. Kirk Patel, Hemal H. Roth, David M. |
author_facet | Ichikawa, Yasuhiro Zemljic-Harpf, Alice E. Zhang, Zheng McKirnan, M. Dan Manso, Ana Maria Ross, Robert S. Hammond, H. Kirk Patel, Hemal H. Roth, David M. |
author_sort | Ichikawa, Yasuhiro |
collection | PubMed |
description | Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart. Rabbits were administered daunorubicin (3 mg/kg, IV) weekly, for three weeks or nine weeks. Nine weeks but not three weeks of daunorubicin resulted in progressive reduced left ventricular function. Cav-3 expression in the heart was unchanged at three weeks of daunorubicin and increased in nine week treated rabbits when compared to control hearts. Electron microscopy showed caveolae in the heart were increased and mitochondrial number and size were decreased after nine weeks of daunorubicin. Activated beta-1 (β1) integrin and the membrane repair protein MG53 were increased after nine weeks of daunorubicin vs. controls with no change at the three week time point. The results suggest a potential pathophysiological role for Cav3, integrins and membrane repair in daunorubicin-induced heart failure. |
format | Online Article Text |
id | pubmed-5428970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54289702017-05-26 Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits Ichikawa, Yasuhiro Zemljic-Harpf, Alice E. Zhang, Zheng McKirnan, M. Dan Manso, Ana Maria Ross, Robert S. Hammond, H. Kirk Patel, Hemal H. Roth, David M. PLoS One Research Article Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart. Rabbits were administered daunorubicin (3 mg/kg, IV) weekly, for three weeks or nine weeks. Nine weeks but not three weeks of daunorubicin resulted in progressive reduced left ventricular function. Cav-3 expression in the heart was unchanged at three weeks of daunorubicin and increased in nine week treated rabbits when compared to control hearts. Electron microscopy showed caveolae in the heart were increased and mitochondrial number and size were decreased after nine weeks of daunorubicin. Activated beta-1 (β1) integrin and the membrane repair protein MG53 were increased after nine weeks of daunorubicin vs. controls with no change at the three week time point. The results suggest a potential pathophysiological role for Cav3, integrins and membrane repair in daunorubicin-induced heart failure. Public Library of Science 2017-05-12 /pmc/articles/PMC5428970/ /pubmed/28498861 http://dx.doi.org/10.1371/journal.pone.0177660 Text en © 2017 Ichikawa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ichikawa, Yasuhiro Zemljic-Harpf, Alice E. Zhang, Zheng McKirnan, M. Dan Manso, Ana Maria Ross, Robert S. Hammond, H. Kirk Patel, Hemal H. Roth, David M. Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title | Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title_full | Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title_fullStr | Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title_full_unstemmed | Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title_short | Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
title_sort | modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428970/ https://www.ncbi.nlm.nih.gov/pubmed/28498861 http://dx.doi.org/10.1371/journal.pone.0177660 |
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