Cargando…

Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells

Allicin is considered anti-atherosclerotic due to its antioxidant and anti-inflammatory effects, which makes it an important drug for the prevention and treatment of atherosclerosis. However, the effects of allicin on foam cells are unclear. Thus, in this study, we examined the effects of allicin on...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Xiao-Long, Hu, Hui-Jun, Liu, Yuan-Bo, Hu, Xue-Mei, Fan, Xiao-Juan, Zou, Wei-Wen, Pan, Yong-Quan, Zhou, Wen-Quan, Peng, Min-Wen, Gu, Cai-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428973/ https://www.ncbi.nlm.nih.gov/pubmed/28440421 http://dx.doi.org/10.3892/ijmm.2017.2949

Ejemplares similares

Septin 4 activates PPARγ/LXRα signaling by upregulating ABCA1 and ABCG1 expression to inhibit the formation of THP-1 macrophage-derived foam cells
por: Song, Xiaoying, et al.
Publicado: (2021)

Hydroxytyrosol Reduces Foam Cell Formation and Endothelial Inflammation Regulating the PPARγ/LXRα/ABCA1 Pathway
por: Franceschelli, Sara, et al.
Publicado: (2023)

Sini Decoction Intervention on Atherosclerosis via PPARγ-LXRα-ABCA1 Pathway in Rabbits
por: Ju, Shicong, et al.
Publicado: (2018)

Atheroprotective Effect of Fucoidan in THP-1 Macrophages by Potential Upregulation of ABCA1
por: Mirza, Zeenat, et al.
Publicado: (2023)

Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway
por: Li, Heng, et al.
Publicado: (2022)

Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque
por: Wang, Huan, et al.
Publicado: (2018)

Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-γ/LXR-α/ABCA1 Pathway
por: Zhang, Zepeng, et al.
Publicado: (2020)

Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1
por: Jia, Qingling, et al.
Publicado: (2019)

Knockdown of mesenchymal stem cell-derived exosomal LOC100129516 suppresses the symptoms of atherosclerosis via upregulation of the PPARγ/LXRα/ABCA1 signaling pathway
por: Sun, Limin, et al.
Publicado: (2021)

Knockdown of mesenchymal stem cell-derived exosomal LOC100129516 suppresses the symptoms of atherosclerosis via upregulation of the PPARγ/LXRα/ABCA1 signaling pathway
por: Sun, Limin, et al.
Publicado: (2022)

PAK1 Silencing Attenuated Proinflammatory Macrophage Activation and Foam Cell Formation by Increasing PPARγ Expression
por: Cheng, Wen-Lin, et al.
Publicado: (2021)

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages
por: Wang, Limei, et al.
Publicado: (2015)

Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner
por: Chen, Xuanjing, et al.
Publicado: (2021)

Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4-Mediated Downregulation of PPARγ/LXRα/ABCA1 in ApoE(-/-) Mice
por: Gu, Hong-Feng, et al.
Publicado: (2019)

Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-γ/LXR-α/ABCA1 in macrophages
por: Liang, Ling, et al.
Publicado: (2021)

RXRα is Upregulated in First Trimester Endometrial Glands of Spontaneous Abortions Unlike LXR and PPARγ
por: Knabl, J., et al.
Publicado: (2016)

PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
por: Majdalawieh, Amin, et al.
Publicado: (2010)

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux
por: Nelson, Jessica Kristine, et al.
Publicado: (2017)

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP‐1‐derived macrophages
por: Wang, Limei, et al.
Publicado: (2016)

Crocin ameliorates atherosclerosis by promoting the reverse cholesterol transport and inhibiting the foam cell formation via regulating PPARγ/LXR-α
por: Zhang, Feng, et al.
Publicado: (2022)

PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection
por: Hanley, Timothy M., et al.
Publicado: (2010)

LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2
por: Hussein, Maryem A., et al.
Publicado: (2015)

Effects of miR-33a-5P on ABCA1/G1-Mediated Cholesterol Efflux under Inflammatory Stress in THP-1 Macrophages
por: Mao, Min, et al.
Publicado: (2014)

Expression of LXR-β, ABCA1 and ABCG1 in human triple-negative breast cancer tissues
por: Pan, Hailing, et al.
Publicado: (2019)

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages
por: Mota, Ana Carolina, et al.
Publicado: (2021)

Foam Cell Specific LXRα Ligand
por: Feldmann, Radmila, et al.
Publicado: (2013)

Inhibition of Hydrogen Peroxide-Induced Human Umbilical Vein Endothelial Cells Aging by Allicin Depends on Sirtuin1 Activation
por: Lin, Xiao-Long, et al.
Publicado: (2017)

Microarray Expression Profile of Myricetin-Treated THP-1 Macrophages Exhibits Alterations in Atherosclerosis-Related Regulator Molecules and LXR/RXR Pathway
por: Huwait, Etimad, et al.
Publicado: (2022)

Oxidized LDL Downregulates ABCA1 Expression via MEK/ERK/LXR Pathway in INS-1 Cells
por: Lyu, Jingya, et al.
Publicado: (2021)

LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1
por: Patel, Deven, et al.
Publicado: (2019)

Protective Effects of Platycodin D on Lipopolysaccharide-Induced Acute Lung Injury by Activating LXRα–ABCA1 Signaling Pathway
por: Hu, Xiaoyu, et al.
Publicado: (2017)

Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage
por: Zhang, Heng, et al.
Publicado: (2015)

Polyunsaturated Fatty Acids and Modulation of Cholesterol Homeostasis in THP-1 Macrophage-Derived Foam Cells
por: Salehipour, Masoud, et al.
Publicado: (2010)

Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages
por: Wang, Limei, et al.
Publicado: (2017)

The Dietary Constituent Falcarindiol Promotes Cholesterol Efflux from THP-1 Macrophages by Increasing ABCA1 Gene Transcription and Protein Stability
por: Wang, Limei, et al.
Publicado: (2017)

PPARγ Ameliorates Mycobacterium tuberculosis H37Ra-Induced Foamy Macrophage Formation via the ABCG1-Dependent Cholesterol Efflux Pathway in THP-1 Macrophages
por: Ye, Yutao, et al.
Publicado: (2022)

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα
por: Goldwasser, Jonathan, et al.
Publicado: (2010)

5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway
por: Shinohara, Motoko, et al.
Publicado: (2019)

Antileukemic activity of sulfoxide nutraceutical allicin against THP-1 cells is associated with premature phosphatidylserine exposure in human erythrocytes
por: Sultan, Samar A., et al.
Publicado: (2020)

Inhibition of LXR controls the polarization of human inflammatory macrophages through upregulation of MAFB
por: de la Aleja, Arturo González, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_av15regbp5b6tteob9vc0ji07b