Cargando…

Extraordinary effects of unnatural pairings

Engineered molecules based on human cytokines have potential uses in research and medicine.

Detalles Bibliográficos
Autores principales:	Villarino, Alejandro, O'Shea, John J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429087/ https://www.ncbi.nlm.nih.gov/pubmed/28498100 http://dx.doi.org/10.7554/eLife.27198

Ejemplares similares

Spectral analysis of pair-correlation bandwidth: application to cell biology images
por: Binder, Benjamin J., et al.
Publicado: (2015)

Sequence-dependent base pair stepping dynamics in XPD helicase unwinding
por: Qi, Zhi, et al.
Publicado: (2013)

Visualization and functional dissection of coaxial paired SpoIIIE channels across the sporulation septum
por: Shin, Jae Yen, et al.
Publicado: (2015)

Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide
por: Singh, Isha, et al.
Publicado: (2018)

Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor
por: Cooley, Richard B, et al.
Publicado: (2016)

Effect of microstructure on the mechanical and damping behaviour of dragonfly wing veins
por: Rajabi, H., et al.
Publicado: (2016)

9Å structure of the COPI coat reveals that the Arf1 GTPase occupies two contrasting molecular environments
por: Dodonova, Svetlana O, et al.
Publicado: (2017)

Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
por: Trajtenberg, Felipe, et al.
Publicado: (2016)

Hexameric helicase G40P unwinds DNA in single base pair steps
por: Schlierf, Michael, et al.
Publicado: (2019)

Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)

Correction: Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)

Pre-transition effects mediate forces of assembly between transmembrane proteins
por: Katira, Shachi, et al.
Publicado: (2016)

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function
por: Vijayvargia, Ravi, et al.
Publicado: (2016)

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
por: O'Donoghue, Geoff P, et al.
Publicado: (2013)

Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones
por: Wilkinson, Martin, et al.
Publicado: (2016)

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2
por: Kimanius, Dari, et al.
Publicado: (2016)

Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction
por: Elwell, Cherilyn A, et al.
Publicado: (2017)

Binary architecture of the Na(v)1.2-β2 signaling complex
por: Das, Samir, et al.
Publicado: (2016)

Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family
por: Arkhipov, Anton, et al.
Publicado: (2013)

Compaction and segregation of sister chromatids via active loop extrusion
por: Goloborodko, Anton, et al.
Publicado: (2016)

Deconstruction of the Ras switching cycle through saturation mutagenesis
por: Bandaru, Pradeep, et al.
Publicado: (2017)

An internal thioester in a pathogen surface protein mediates covalent host binding
por: Walden, Miriam, et al.
Publicado: (2015)

Aerotaxis in the closest relatives of animals
por: Kirkegaard, Julius B, et al.
Publicado: (2016)

Bringing dead proteins back to life
por: A Wustman, Brandon, et al.
Publicado: (2014)

Selection of chromosomal DNA libraries using a multiplex CRISPR system
por: Ryan, Owen W, et al.
Publicado: (2014)

Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps
por: Singharoy, Abhishek, et al.
Publicado: (2016)

Examining kinesin processivity within a general gating framework
por: Andreasson, Johan OL, et al.
Publicado: (2015)

Mechanistic insight into the conserved allosteric regulation of periplasmic proteolysis by the signaling molecule cyclic-di-GMP
por: Chatterjee, Debashree, et al.
Publicado: (2014)

Dilation of fusion pores by crowding of SNARE proteins
por: Wu, Zhenyong, et al.
Publicado: (2017)

Nanoscale protein architecture of the kidney glomerular basement membrane
por: Suleiman, Hani, et al.
Publicado: (2013)

Correction: Nanoscale protein architecture of the kidney glomerular basement membrane
por: Suleiman, Hani, et al.
Publicado: (2013)

Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1
por: Jia, Xiaofei, et al.
Publicado: (2014)

Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4
por: Nicoludis, John M, et al.
Publicado: (2016)

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling
por: Primorac, Ivana, et al.
Publicado: (2013)

Structure and dynamics underlying elementary ligand binding events in human pacemaking channels
por: Goldschen-Ohm, Marcel P, et al.
Publicado: (2016)

Disordered clusters of Bak dimers rupture mitochondria during apoptosis
por: Uren, Rachel T, et al.
Publicado: (2017)

A structural model of the active ribosome-bound membrane protein insertase YidC
por: Wickles, Stephan, et al.
Publicado: (2014)

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
por: Nwachukwu, Jerome C, et al.
Publicado: (2014)

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1
por: Iwig, Jeffrey S, et al.
Publicado: (2013)

Bacterial flagella grow through an injection-diffusion mechanism
por: Renault, Thibaud T, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6d73d94as2e38pc7s5ktd0com7