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Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity
Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amph...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429095/ https://www.ncbi.nlm.nih.gov/pubmed/28395144 http://dx.doi.org/10.7554/eLife.22194 |
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author | Gaiti, Federico Jindrich, Katia Fernandez-Valverde, Selene L Roper, Kathrein E Degnan, Bernard M Tanurdžić, Miloš |
author_facet | Gaiti, Federico Jindrich, Katia Fernandez-Valverde, Selene L Roper, Kathrein E Degnan, Bernard M Tanurdžić, Miloš |
author_sort | Gaiti, Federico |
collection | PubMed |
description | Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity. DOI: http://dx.doi.org/10.7554/eLife.22194.001 |
format | Online Article Text |
id | pubmed-5429095 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54290952017-05-15 Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity Gaiti, Federico Jindrich, Katia Fernandez-Valverde, Selene L Roper, Kathrein E Degnan, Bernard M Tanurdžić, Miloš eLife Developmental Biology and Stem Cells Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity. DOI: http://dx.doi.org/10.7554/eLife.22194.001 eLife Sciences Publications, Ltd 2017-04-11 /pmc/articles/PMC5429095/ /pubmed/28395144 http://dx.doi.org/10.7554/eLife.22194 Text en © 2017, Gaiti et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology and Stem Cells Gaiti, Federico Jindrich, Katia Fernandez-Valverde, Selene L Roper, Kathrein E Degnan, Bernard M Tanurdžić, Miloš Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title_full | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title_fullStr | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title_full_unstemmed | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title_short | Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
title_sort | landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity |
topic | Developmental Biology and Stem Cells |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429095/ https://www.ncbi.nlm.nih.gov/pubmed/28395144 http://dx.doi.org/10.7554/eLife.22194 |
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