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A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma

BACKGROUND: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. OBJECTIVE: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year per...

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Autores principales: Viana, Ana Carolina Leite, Goulart, Eugênio Marcos Andrade, Gontijo, Bernardo, Bittencourt, Flávia Vasques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429105/
https://www.ncbi.nlm.nih.gov/pubmed/28538879
http://dx.doi.org/10.1590/abd1806-4841.20175176
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author Viana, Ana Carolina Leite
Goulart, Eugênio Marcos Andrade
Gontijo, Bernardo
Bittencourt, Flávia Vasques
author_facet Viana, Ana Carolina Leite
Goulart, Eugênio Marcos Andrade
Gontijo, Bernardo
Bittencourt, Flávia Vasques
author_sort Viana, Ana Carolina Leite
collection PubMed
description BACKGROUND: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. OBJECTIVE: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. METHODS: Our prospective cohort included only patients with congenital nevi ≥20cm. The cumulative risk of developing melanoma and the standardized morbidity ratio were calculated for patients followed up prospectively for at least 1 month. RESULTS: Sixty-three patients were enrolled in this study. One patient who developed melanoma prior to enrollment was excluded, and five were eliminated because of insufficient follow-up time. Mean follow-up for the remaining 57 patients was 5.5 years (median 5.2 years). Median age of entry into the study was 2.6 years. Most patients (75.4%) underwent only clinical observation. Melanomas occurred in 2 (3.5%) patients. Five-year cumulative risk for melanoma was 4.8% (95% CI: 1.9-11.5%). Standardized morbidity ratio was 1584 (95% CI: 266-5232, p<0.001). STUDY LIMITATIONS: The small sample size reduces the accuracy of risk estimates. CONCLUSIONS: This study analyzed prospectively for the first time data from South America demonstrating that patients with LCMN have a higher risk of developing melanoma than the general population (p<0.001).
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spelling pubmed-54291052017-05-17 A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma Viana, Ana Carolina Leite Goulart, Eugênio Marcos Andrade Gontijo, Bernardo Bittencourt, Flávia Vasques An Bras Dermatol Investigation BACKGROUND: Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. OBJECTIVE: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. METHODS: Our prospective cohort included only patients with congenital nevi ≥20cm. The cumulative risk of developing melanoma and the standardized morbidity ratio were calculated for patients followed up prospectively for at least 1 month. RESULTS: Sixty-three patients were enrolled in this study. One patient who developed melanoma prior to enrollment was excluded, and five were eliminated because of insufficient follow-up time. Mean follow-up for the remaining 57 patients was 5.5 years (median 5.2 years). Median age of entry into the study was 2.6 years. Most patients (75.4%) underwent only clinical observation. Melanomas occurred in 2 (3.5%) patients. Five-year cumulative risk for melanoma was 4.8% (95% CI: 1.9-11.5%). Standardized morbidity ratio was 1584 (95% CI: 266-5232, p<0.001). STUDY LIMITATIONS: The small sample size reduces the accuracy of risk estimates. CONCLUSIONS: This study analyzed prospectively for the first time data from South America demonstrating that patients with LCMN have a higher risk of developing melanoma than the general population (p<0.001). Sociedade Brasileira de Dermatologia 2017 /pmc/articles/PMC5429105/ /pubmed/28538879 http://dx.doi.org/10.1590/abd1806-4841.20175176 Text en ©2017 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Investigation
Viana, Ana Carolina Leite
Goulart, Eugênio Marcos Andrade
Gontijo, Bernardo
Bittencourt, Flávia Vasques
A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title_full A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title_fullStr A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title_full_unstemmed A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title_short A prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
title_sort prospective study of patients with large congenital melanocytic nevi and the risk of melanoma
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429105/
https://www.ncbi.nlm.nih.gov/pubmed/28538879
http://dx.doi.org/10.1590/abd1806-4841.20175176
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