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Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015

BACKGROUND: Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinatal features. METHODS: A retrospective study was performed based on provincial bi...

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Autores principales: Zhang, Xiao-Hui, Qiu, Li-Qian, Ye, Ying-Hui, Xu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429550/
https://www.ncbi.nlm.nih.gov/pubmed/28499441
http://dx.doi.org/10.1186/s13052-017-0363-y
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author Zhang, Xiao-Hui
Qiu, Li-Qian
Ye, Ying-Hui
Xu, Jian
author_facet Zhang, Xiao-Hui
Qiu, Li-Qian
Ye, Ying-Hui
Xu, Jian
author_sort Zhang, Xiao-Hui
collection PubMed
description BACKGROUND: Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinatal features. METHODS: A retrospective study was performed based on provincial birth defects surveillance data. The relative risk (RR) and 95% confidence interval (CI) were used to calculate maternal age-specific rates of CA. Socio-demographic characteristics of mothers and perinatal features were listed. RESULTS: The total prevalence of CA was 6.38 per 10,000 births, which increased per 10,000 births linearly from 4.02 in 2011 to 9.13 in 2015 (x (2) (line-trend) =52.69, p < 0.001). During this period, the prevalence for CA per 10,000 births among women over 35 years old increased from 15.34 in 2011 to 33.82 in 2015 (x (2) (line-trend) =115121.6, p < 0.001). The RR for overall CA, trisomy 21(T21), trisomy 18(T18) and others in mothers 35 years or older were 6.64 (95% CI 5.55 ~ 7.93), 6.83 (95% CI 5.63 ~ 8.30), 4.06 (95% CI 2.09 ~ 7.90) and 7.54 (95% CI 4.02 ~ 14.11) respectively in comparison to mothers aged 25–29 years old. The stillbirths rate for total CA was 76.45%. T21 and T18 were strongly associated with multiple anomalies, especially congenital heart abnormalities. CONCLUSIONS: The prevalence of CA increased as maternal age increased. Cases with CA were associated with other congenital defects and high mortality risk.
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spelling pubmed-54295502017-05-15 Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015 Zhang, Xiao-Hui Qiu, Li-Qian Ye, Ying-Hui Xu, Jian Ital J Pediatr Research BACKGROUND: Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinatal features. METHODS: A retrospective study was performed based on provincial birth defects surveillance data. The relative risk (RR) and 95% confidence interval (CI) were used to calculate maternal age-specific rates of CA. Socio-demographic characteristics of mothers and perinatal features were listed. RESULTS: The total prevalence of CA was 6.38 per 10,000 births, which increased per 10,000 births linearly from 4.02 in 2011 to 9.13 in 2015 (x (2) (line-trend) =52.69, p < 0.001). During this period, the prevalence for CA per 10,000 births among women over 35 years old increased from 15.34 in 2011 to 33.82 in 2015 (x (2) (line-trend) =115121.6, p < 0.001). The RR for overall CA, trisomy 21(T21), trisomy 18(T18) and others in mothers 35 years or older were 6.64 (95% CI 5.55 ~ 7.93), 6.83 (95% CI 5.63 ~ 8.30), 4.06 (95% CI 2.09 ~ 7.90) and 7.54 (95% CI 4.02 ~ 14.11) respectively in comparison to mothers aged 25–29 years old. The stillbirths rate for total CA was 76.45%. T21 and T18 were strongly associated with multiple anomalies, especially congenital heart abnormalities. CONCLUSIONS: The prevalence of CA increased as maternal age increased. Cases with CA were associated with other congenital defects and high mortality risk. BioMed Central 2017-05-12 /pmc/articles/PMC5429550/ /pubmed/28499441 http://dx.doi.org/10.1186/s13052-017-0363-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhang, Xiao-Hui
Qiu, Li-Qian
Ye, Ying-Hui
Xu, Jian
Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title_full Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title_fullStr Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title_full_unstemmed Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title_short Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
title_sort chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of china, 2011–2015
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429550/
https://www.ncbi.nlm.nih.gov/pubmed/28499441
http://dx.doi.org/10.1186/s13052-017-0363-y
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