The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be assisted by host cell factors. Here we investigate...

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Detalles Bibliográficos
Autores principales: Schuster, Manuel, Schnell, Leonie, Feigl, Peter, Birkhofer, Carina, Mohr, Katharina, Roeder, Maurice, Carle, Stefan, Langer, Simon, Tippel, Franziska, Buchner, Johannes, Fischer, Gunter, Hausch, Felix, Frick, Manfred, Schwan, Carsten, Aktories, Klaus, Schiene-Fischer, Cordelia, Barth, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429619/
https://www.ncbi.nlm.nih.gov/pubmed/28377614
http://dx.doi.org/10.1038/s41598-017-00780-x

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