Biochemical analysis of leishmanial and human GDP-Mannose Pyrophosphorylases and selection of inhibitors as new leads

Leishmaniases are an ensemble of diseases caused by the protozoan parasite of the genus Leishmania. Current antileishmanial treatments are limited and present main issues of toxicity and drug resistance emergence. Therefore, the generation of new inhibitors specifically directed against a leishmania...

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Detalles Bibliográficos
Autores principales: Mao, Wei, Daligaux, Pierre, Lazar, Noureddine, Ha-Duong, Tâp, Cavé, Christian, van Tilbeurgh, Herman, Loiseau, Philippe M., Pomel, Sébastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429698/
https://www.ncbi.nlm.nih.gov/pubmed/28389670
http://dx.doi.org/10.1038/s41598-017-00848-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429698/
https://www.ncbi.nlm.nih.gov/pubmed/28389670
http://dx.doi.org/10.1038/s41598-017-00848-8

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